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Literature summary for 1.11.1.28 extracted from

  • Alegria, T.; Meireles, D.; Cussiol, J.; Hugo, M.; Trujillo, M.; De Oliveira, M.; Miyamoto, S.; Queiroz, R.; Valadares, N.; Garratt, R.; Radi, R.; Di Mascio, P.; Augusto, O.; Netto, L.
    Ohr plays a central role in bacterial responses against fatty acid hydroperoxides and peroxynitrite (2017), Proc. Natl. Acad. Sci. USA, 114, E132-E141 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
Tween-20 0.25%, the enzyme retains more than 80% of its original activity toward tert-butyl hydroperoxide. The activity toward LAOOH is maximal Xylella fastidiosa

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa A0A0H2ZCJ7
-
-
Pseudomonas aeruginosa UCBPP-PA14 A0A0H2ZCJ7
-
-
Xylella fastidiosa Q9PCF4
-
-
Xylella fastidiosa 9a5c Q9PCF4
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a [lipoyl-carrier protein]-N6-[(R)-dihydrolipoyl]-L-lysine + linoleic acid hydroperoxide
-
Xylella fastidiosa a [lipoyl-carrier protein]-N6-lipoyl-L-lysine + H2O + ?
-
?
a [lipoyl-carrier protein]-N6-[(R)-dihydrolipoyl]-L-lysine + linoleic acid hydroperoxide
-
Xylella fastidiosa 9a5c a [lipoyl-carrier protein]-N6-lipoyl-L-lysine + H2O + ?
-
?
a [lipoyl-carrier protein]-N6-[(R)-dihydrolipoyl]-L-lysine + ROOH
-
Pseudomonas aeruginosa a [lipoyl-carrier protein]-N6-lipoyl-L-lysine + H2O + ROH
-
?
a [lipoyl-carrier protein]-N6-[(R)-dihydrolipoyl]-L-lysine + ROOH
-
Pseudomonas aeruginosa UCBPP-PA14 a [lipoyl-carrier protein]-N6-lipoyl-L-lysine + H2O + ROH
-
?
a [lipoyl-carrier protein]-N6-[(R)-dihydrolipoyl]-L-lysine + tert-butyl hydroperoxide fatty acid (but not cholesterol) hydroperoxides dock well into the active site of Ohr from Xylella fastidiosa and are efficiently reduced by the recombinant enzyme Xylella fastidiosa a [lipoyl-carrier protein]-N6-lipoyl-L-lysine + H2O + tert-butanol
-
?
a [lipoyl-carrier protein]-N6-[(R)-dihydrolipoyl]-L-lysine + tert-butyl hydroperoxide fatty acid (but not cholesterol) hydroperoxides dock well into the active site of Ohr from Xylella fastidiosa and are efficiently reduced by the recombinant enzyme Xylella fastidiosa 9a5c a [lipoyl-carrier protein]-N6-lipoyl-L-lysine + H2O + tert-butanol
-
?

Synonyms

Synonyms Comment Organism
Ohr
-
Xylella fastidiosa
Ohr
-
Pseudomonas aeruginosa
Organic hydroperoxide resistance
-
Xylella fastidiosa
Organic hydroperoxide resistance
-
Pseudomonas aeruginosa

Expression

Organism Comment Expression
Xylella fastidiosa expression of ohr is induced in cells exposed to 3-morpholinosydnonimine hydrochloride up
Pseudomonas aeruginosa expression of ohr is induced in cells exposed to 3-morpholinosydnonimine hydrochloride up

General Information

General Information Comment Organism
malfunction DELTAohr strain presents a reduced capacity to grow in the presence of either artificial (cumene hydroperoxide and tert-butyl hydroperoxide) or fatty acid hydroperoxides compared with the wild type Pseudomonas aeruginosa
physiological function Ohr plays a central role in bacterial responses against fatty acid hydroperoxides and peroxynitrite Xylella fastidiosa
physiological function the enzyme is involved in the Pseudomonas aeruginosa response to fatty acid hydroperoxides and to peroxynitrite. Therefore, Ohr plays central roles in the bacterial response to two hydroperoxides that are at the host-pathogen interface Pseudomonas aeruginosa