Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Tween-20 | 0.25%, the enzyme retains more than 80% of its original activity toward tert-butyl hydroperoxide. The activity toward LAOOH is maximal | Xylella fastidiosa |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas aeruginosa | A0A0H2ZCJ7 | - |
- |
Pseudomonas aeruginosa UCBPP-PA14 | A0A0H2ZCJ7 | - |
- |
Xylella fastidiosa | Q9PCF4 | - |
- |
Xylella fastidiosa 9a5c | Q9PCF4 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
a [lipoyl-carrier protein]-N6-[(R)-dihydrolipoyl]-L-lysine + linoleic acid hydroperoxide | - |
Xylella fastidiosa | a [lipoyl-carrier protein]-N6-lipoyl-L-lysine + H2O + ? | - |
? | |
a [lipoyl-carrier protein]-N6-[(R)-dihydrolipoyl]-L-lysine + linoleic acid hydroperoxide | - |
Xylella fastidiosa 9a5c | a [lipoyl-carrier protein]-N6-lipoyl-L-lysine + H2O + ? | - |
? | |
a [lipoyl-carrier protein]-N6-[(R)-dihydrolipoyl]-L-lysine + ROOH | - |
Pseudomonas aeruginosa | a [lipoyl-carrier protein]-N6-lipoyl-L-lysine + H2O + ROH | - |
? | |
a [lipoyl-carrier protein]-N6-[(R)-dihydrolipoyl]-L-lysine + ROOH | - |
Pseudomonas aeruginosa UCBPP-PA14 | a [lipoyl-carrier protein]-N6-lipoyl-L-lysine + H2O + ROH | - |
? | |
a [lipoyl-carrier protein]-N6-[(R)-dihydrolipoyl]-L-lysine + tert-butyl hydroperoxide | fatty acid (but not cholesterol) hydroperoxides dock well into the active site of Ohr from Xylella fastidiosa and are efficiently reduced by the recombinant enzyme | Xylella fastidiosa | a [lipoyl-carrier protein]-N6-lipoyl-L-lysine + H2O + tert-butanol | - |
? | |
a [lipoyl-carrier protein]-N6-[(R)-dihydrolipoyl]-L-lysine + tert-butyl hydroperoxide | fatty acid (but not cholesterol) hydroperoxides dock well into the active site of Ohr from Xylella fastidiosa and are efficiently reduced by the recombinant enzyme | Xylella fastidiosa 9a5c | a [lipoyl-carrier protein]-N6-lipoyl-L-lysine + H2O + tert-butanol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Ohr | - |
Xylella fastidiosa |
Ohr | - |
Pseudomonas aeruginosa |
Organic hydroperoxide resistance | - |
Xylella fastidiosa |
Organic hydroperoxide resistance | - |
Pseudomonas aeruginosa |
Organism | Comment | Expression |
---|---|---|
Xylella fastidiosa | expression of ohr is induced in cells exposed to 3-morpholinosydnonimine hydrochloride | up |
Pseudomonas aeruginosa | expression of ohr is induced in cells exposed to 3-morpholinosydnonimine hydrochloride | up |
General Information | Comment | Organism |
---|---|---|
malfunction | DELTAohr strain presents a reduced capacity to grow in the presence of either artificial (cumene hydroperoxide and tert-butyl hydroperoxide) or fatty acid hydroperoxides compared with the wild type | Pseudomonas aeruginosa |
physiological function | Ohr plays a central role in bacterial responses against fatty acid hydroperoxides and peroxynitrite | Xylella fastidiosa |
physiological function | the enzyme is involved in the Pseudomonas aeruginosa response to fatty acid hydroperoxides and to peroxynitrite. Therefore, Ohr plays central roles in the bacterial response to two hydroperoxides that are at the host-pathogen interface | Pseudomonas aeruginosa |