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Literature summary for 1.11.1.27 extracted from

  • Pankiewicz, J.E.; Diaz, J.R.; Marta-Ariza, M.; Lizi?czyk, A.M.; Franco, L.A.; Sadowski, M.J.
    Peroxiredoxin 6 mediates protective function of astrocytes in Abeta proteostasis (2020), Mol. Neurodegener., 15, 50 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 glutathione + ROOH Mus musculus
-
 glutathione disulfide + H2O + ROH
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 glutathione + ROOH
-
 Mus musculus glutathione disulfide + H2O + ROH
-
 ?

Subunits

Subunits Comment Organism
? x * 25000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
peroxiredoxin 6 dual function enzyme with independent glutathione peroxidase and phospholipase A2 activities Mus musculus
Prdx6
-
 Mus musculus

General Information

General Information Comment Organism
malfunction enzyme haplodeficiency attenuates astro- and microglia activation around Abeta plaques promoting Abeta deposition and neuritic degeneration Mus musculus
physiological function enzyme upregulation attenuates Abeta pathology Mus musculus