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Literature summary for 1.11.1.27 extracted from

  • Arevalo, J.A.; Vazquez-Medina, J.P.
    The role of peroxiredoxin 6 in cell signaling (2018), Antioxidants (Basel), 7, 172 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.11.1.27

Organism

Organism UniProt Comment Textmining
Homo sapiens P30041
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Mus musculus O08709
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Synonyms

Synonyms Comment Organism
peroxiredoxin 6
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 Homo sapiens
peroxiredoxin 6
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 Mus musculus
Prdx6
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 Homo sapiens
Prdx6 cf. EC 3.1.1.4 Mus musculus

General Information

General Information Comment Organism
physiological function Prdx6 plays crucial roles in lung phospholipid metabolism, lipid peroxidation repair, and inflammatory signaling. Mice that over-express Prdx6 show a greater increase in the growth of lung tumors compared to wild-type animals. Both aiPLA2 and Prdx6 peroxidase activities are implicated in lung tumor development through the regulation of redox-sensitive pathways such as MAPK, JNK, JAK/STAT, and AP-1 Mus musculus
physiological function Prdx6 plays crucial roles in lung phospholipid metabolism, lipid peroxidation repair, and inflammatory signaling. Prdx6 prevents oxidative stress in human retinal pigment epithelial cells by activating the phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) pathway. Prdx6 is necessary to prevent cataract formation and to limit aging-induced oxidative stress in the eye Homo sapiens