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Literature summary for 1.11.1.26 extracted from

  • Alharbi, A.; Rabadi, S.M.; Alqahtani, M.; Marghani, D.; Worden, M.; Ma, Z.; Malik, M.; Bakshi, C.S.
    Role of peroxiredoxin of the AhpC/TSA family in antioxidant defense mechanisms of Francisella tularensis (2019), PLoS One, 14, e0213699 .
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Francisella tularensis subsp. holarctica
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Francisella tularensis subsp. holarctica A0A0B3VNJ6
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Francisella tularensis subsp. holarctica LVS
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Francisella tularensis subsp. holarctica LVS A0A0B3VNJ6
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Francisella tularensis subsp. tularensis
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Francisella tularensis subsp. tularensis A0A0B3VNJ6
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Francisella tularensis subsp. tularensis SchuS4
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Synonyms

Synonyms Comment Organism
AhpC
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Francisella tularensis subsp. holarctica
AhpC
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Francisella tularensis subsp. tularensis
FTL_1015
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Francisella tularensis subsp. holarctica
FTT_0557
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Francisella tularensis subsp. tularensis

General Information

General Information Comment Organism
malfunction the enzyme-deficient mutant is attenuated for intramacrophage growth Francisella tularensis subsp. tularensis
malfunction the enzyme-deficient mutant reveals enhanced sensitivities towards superoxide-generating compounds as indicated by significantly larger zones of inhibition around the discs impregnated with menadione, pyrogallol and paraquat as compared to those observed for wild type enzyme. The enzyme-deficient mutant exhibits enhanced sensitivity towards reactive nitrogen species, organic peroxides and H2O2, does not exhibit intramacrophage growth defect but is attenuated for virulence in mice Francisella tularensis subsp. holarctica
physiological function AhpC of Francisella tularensis LVS confers resistance against a wide range of reactive oxygen and nitrogen species, and serves as a virulence factor Francisella tularensis subsp. holarctica
physiological function in highly virulent Francisella tularensis SCHU S4 strain, AhpC serves as a key antioxidant enzyme and contributes to its robust oxidative and nitrosative stress resistance, and intramacrophage survival Francisella tularensis subsp. tularensis
physiological function the enzyme confers resistance against a wide range of reactive oxygen and nitrogen species, and serves as a virulence factor Francisella tularensis subsp. holarctica
physiological function the enzyme serves as a key antioxidant enzyme and contributes to its robust oxidative and nitrosative stress resistance, and intramacrophage survival Francisella tularensis subsp. tularensis