Inhibitors | Comment | Organism | Structure |
---|---|---|---|
H2O2 | excess of H2O2 inactivates the enzyme by overoxidation | Homo sapiens | |
peroxynitrite | excess of peroxynitrite inactivates the enzyme by overoxidation | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0007 | - |
H2O2 | Km below 0.0007 mM, at 25°C and pH 7.4 | Homo sapiens | |
0.0024 | - |
reduced thioredoxin | human thioredoxin, at 25°C | Homo sapiens | |
0.004 | - |
reduced thioredoxin | Escherichia coli thioredoxin, at 25°C | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | peroxiredoxin 2 is a key antioxidant enzyme for the erythrocyte and renders red blood cells as active oxidant scrubbers in the bloodstream | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
DEAE-Sepharose column chromatography, Superdex 75 gel filtration, and Superdex 200 gel filtration | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
H2O2 + reduced thioredoxin | - |
Homo sapiens | H2O + oxidized thioredoxin | - |
? | |
additional information | peroxiredoxin 2 is a key antioxidant enzyme for the erythrocyte and renders red blood cells as active oxidant scrubbers in the bloodstream | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
decamer | the enzyme exists as a decamer in vivo, the reduced protein is also a decamer composed of the association of non-covalently linked dimers | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
peroxiredoxin 2 | previously known as torin, calpromotin, NKEF-B, HRPRP, band 8 or TPx-B | Homo sapiens |
Prx2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
thioredoxin | - |
Homo sapiens |