Literature summary for 1.11.1.24 extracted from

Trotter, E.W.; Rand, J.D.; Vickerstaff, J.; Grant, C.M.
The yeast Tsa1 peroxiredoxin is a ribosome-associated antioxidant (2008), Biochem. J., 412, 73-80.

Search for more literature for 1.11.1.24

Protein Variants

Protein Variants	Comment	Organism
C47S	the Cys47 residue of Tsa1 is not required for chaperone activity but is essential for peroxidase activity	Saccharomyces cerevisiae

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	insensitive to hygromycin, paromomycin, and cycloheximide	Saccharomyces cerevisiae

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
ribosome	-	Saccharomyces cerevisiae	5840	-

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
H2O2 + reduced thioredoxin	-	Saccharomyces cerevisiae	H2O + oxidized thioredoxin	-	?

Synonyms

Synonyms	Comment	Organism
Tsa1	has dual activities as a peroxidase and as a molecular chaperone, Tsa1 functions predominantly as an antioxidant in protecting both the cytosol and actively translating ribosomes against endogenous reactive oxygen species, but shifts towards its chaperone function in response to oxidative stress conditions	Saccharomyces cerevisiae

Cofactor

Cofactor	Comment	Organism	Structure
thioredoxin	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)