Literature summary for 1.11.1.24 extracted from

Jang, H.H.; Lee, K.O.; Chi, Y.H.; Jung, B.G.; Park, S.K.; Park, J.H.; Lee, J.R.; Lee, S.S.; Moon, J.C.; Yun, J.W.; Choi, Y.O.; Kim, W.Y.; Kang, J.S.; Cheong, G.W.; Yun, D.J.; Rhee, S.G.; Cho, M.J.; Lee, S.Y.
Two enzymes in one: Two yeast peroxiredoxins display oxidative stress-dependent switching from a peroxidase to a molecular chaperone function (2004), Cell, 117, 625-635.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Saccharomyces cerevisiae

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Saccharomyces cerevisiae	5829	-

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	cPrx I and cPrx II function both as peroxidases and as molecular chaperones. The peroxidase function predominates in the lower molecular weight forms, whereas the chaperone function predominates in the higher molecular weight complexes. Oxidative stress and heat shock exposure of yeasts cause the protein structures of cPrxl and cPrx II to shift from low MW species to high molecular weight complexes. This triggers a peroxidase-to-chaperone functional switch	Saccharomyces cerevisiae	?	-	?

Subunits

Subunits	Comment	Organism
More	recombinant cPrx I produces in Escherichia coli forms differently sized high molecular weight protein structures. cPrx I and cPrx II function both as peroxidases and as molecular chaperones. The peroxidase function predominates in the lower molecular weight forms, whereas the chaperone function predominates in the higher molecular weight complexes. Oxidative stress and heat shock exposure of yeasts cause the protein structures of cPrxl and cPrx II to shift from low MW species to high molecular weight complexes. This triggers a peroxidase-to-chaperone functional switch	Saccharomyces cerevisiae

Synonyms

Synonyms	Comment	Organism
cPrx I	-	Saccharomyces cerevisiae
cPrx II	-	Saccharomyces cerevisiae
Prx	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)