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Literature summary for 1.10.5.1 extracted from

  • Nolan, K.A.; Humphries, M.P.; Barnes, J.; Doncaster, J.R.; Caraher, M.C.; Tirelli, N.; Bryce, R.A.; Whitehead, R.C.; Stratford, I.J.
    Triazoloacridin-6-ones as novel inhibitors of the quinone oxidoreductases NQO1 and NQO2 (2010), Bioorg. Med. Chem., 18, 696-706.
    View publication on PubMed
Search for more literature for 1.10.5.1

Inhibitors

Inhibitors Comment Organism Structure
5-(2-(dimethylamino)ethylamino)-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one
-
 Homo sapiens
5-(2-(dimethylamino)ethylamino)-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one N-oxide
-
 Homo sapiens
5-(2-(dimethylamino)ethylamino)-8-bromo-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one
-
 Homo sapiens
5-(2-(dimethylamino)ethylamino)-8-bromo-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one N-oxide
-
 Homo sapiens
5-(2-(dimethylamino)ethylamino)-8-fluoro-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one
-
 Homo sapiens
5-(2-(dimethylamino)ethylamino)-8-methoxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one
-
 Homo sapiens
5-(2-(dimethylamino)ethylamino)-8-methoxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one N-oxide
-
 Homo sapiens
5-(3-hydroxypropylamino)-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one
-
 Homo sapiens
5-(3-hydroxypropylamino)-8-bromo-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one
-
 Homo sapiens
5-(3-hydroxypropylamino)-8-methoxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one
-
 Homo sapiens
5-(4-methoxyphenylamino)-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one
-
 Homo sapiens
5-(isopentylamino)-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one
-
 Homo sapiens
5-(phenethylamino)-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one
-
 Homo sapiens
8-bromo-5-[(3-methylbutyl)amino]-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one
-
 Homo sapiens
8-methoxy-5-(phenethylamino)-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P16083
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HCT-116 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-benzyldihydronicotinamide + 2,6-dichlorophenolindophenol
-
 Homo sapiens N-benzylnicotamide + reduced 2,6-dichlorophenolindophenol
-
 ?

Synonyms

Synonyms Comment Organism
NQO2
-
 Homo sapiens
NRH:quinone oxidoreductase 2
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000098
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens 5-(4-methoxyphenylamino)-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one
0.000098
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens 5-(2-(dimethylamino)ethylamino)-8-methoxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one N-oxide
0.000117
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens 5-(2-(dimethylamino)ethylamino)-8-bromo-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one N-oxide
0.000167
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens 5-(2-(dimethylamino)ethylamino)-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one N-oxide
0.00035
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens 8-methoxy-5-(phenethylamino)-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one
0.000427
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens 5-(isopentylamino)-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one
0.000483
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens 5-(3-hydroxypropylamino)-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one
0.000517
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens 5-(3-hydroxypropylamino)-8-methoxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one
0.000567
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens 5-(phenethylamino)-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one
0.000767
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens 8-bromo-5-[(3-methylbutyl)amino]-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one
0.000783
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens 5-(2-(dimethylamino)ethylamino)-8-fluoro-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one
0.000987
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens 5-(3-hydroxypropylamino)-8-bromo-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one
0.001333
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens 5-(2-(dimethylamino)ethylamino)-8-methoxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one
0.001483
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens 5-(2-(dimethylamino)ethylamino)-8-bromo-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one
0.001833
-
 in 50 mM phosphate buffer at pH 7.4, at 37°C Homo sapiens 5-(2-(dimethylamino)ethylamino)-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one