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Literature summary for 1.10.5.1 extracted from

  • Maiti, A.; Reddy, P.V.; Sturdy, M.; Marler, L.; Pegan, S.D.; Mesecar, A.D.; Pezzuto, J.M.; Cushman, M.
    Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities (2009), J. Med. Chem., 52, 1873-1884.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.10.5.1

Crystallization (Commentary)

Crystallization (Comment) Organism
X-ray crystallography studies of QR2 in complex with 6-methoxy-9-methyl-[1,3]dioxolo[4,5-h]quinolin-8(9H)-one Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1,4-dimethylquinolin-2(1H)-one
-
 Homo sapiens
5,6,8-trimethoxy-1,4-dimethylquinolin-2(1H)-one
-
 Homo sapiens
5,6,8-trimethoxy-4-methylquinolin-2(1H)-one
-
 Homo sapiens
5,8-dimethoxy-1,4-dimethylquinolin-2(1H)-one
-
 Homo sapiens
5,8-dimethoxy-4-methylquinolin-2(1H)-one
-
 Homo sapiens
6,7,8-trimethoxy-1,4-dimethylquinolin-2(1H)-one
-
 Homo sapiens
6,7,8-trimethoxy-4-methylquinolin-2(1H)-one
-
 Homo sapiens
6,8-dimethoxy-1,4-dimethylquinolin-2(1H)-one
-
 Homo sapiens
6,8-dimethoxy-4-methylquinolin-2(1H)-one
-
 Homo sapiens
6,9-dimethyl-[1,3]dioxolo[4,5-h]quinolin-8(9H)-one
-
 Homo sapiens
6-methoxy-9-methyl-[1,3]dioxolo[4,5-h]quinolin-8(9H)-one
-
 Homo sapiens
6-methyl-[1,3]dioxolo[4,5-h]quinolin-8(9H)-one
-
 Homo sapiens
7,8-dimethoxy-1,4-dimethylquinolin-2(1H)-one
-
 Homo sapiens
7,8-dimethoxy-4-methylquinolin-2(1H)-one
-
 Homo sapiens
8-methoxy-1,4-dimethylquinolin-2(1H)-one
-
 Homo sapiens
8-methoxy-4-methylquinolin-2(1H)-one
-
 Homo sapiens
Melatonin
-
 Homo sapiens
additional information no inhibition by 4-methylquinolin-2(1H)-one. 6-Methoxy-9-methyl-[1,3]dioxolo[4,5-h]quinolin-8(9H)-one and its analogues merit further investigation as potential chemopreventive or chemotherapeutic agents Homo sapiens
resveratrol
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 recombinant
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
QR2
-
 Homo sapiens
quinone reductase 2
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00096
-
 23°C Homo sapiens resveratrol
0.0019
-
 23°C Homo sapiens 6,8-dimethoxy-1,4-dimethylquinolin-2(1H)-one
0.0041
-
 23°C Homo sapiens 5,8-dimethoxy-1,4-dimethylquinolin-2(1H)-one
0.0058
-
 23°C Homo sapiens 8-methoxy-1,4-dimethylquinolin-2(1H)-one
0.006
-
 23°C Homo sapiens 5,6,8-trimethoxy-4-methylquinolin-2(1H)-one
0.0062
-
 23°C Homo sapiens 6,9-dimethyl-[1,3]dioxolo[4,5-h]quinolin-8(9H)-one
0.007
-
 23°C Homo sapiens 6,7,8-trimethoxy-1,4-dimethylquinolin-2(1H)-one
0.0088
-
 23°C Homo sapiens 6,8-dimethoxy-4-methylquinolin-2(1H)-one
0.0093
-
 23°C Homo sapiens 7,8-dimethoxy-1,4-dimethylquinolin-2(1H)-one
0.01
-
 23°C Homo sapiens 6,7,8-trimethoxy-4-methylquinolin-2(1H)-one
0.0108
-
 23°C Homo sapiens 6-methyl-[1,3]dioxolo[4,5-h]quinolin-8(9H)-one
0.0108
-
 23°C Homo sapiens 5,8-dimethoxy-4-methylquinolin-2(1H)-one
0.0108
-
 23°C Homo sapiens 5,6,8-trimethoxy-1,4-dimethylquinolin-2(1H)-one
0.0113
-
 23°C Homo sapiens Melatonin
0.0182
-
 23°C Homo sapiens 1,4-dimethylquinolin-2(1H)-one
0.0241
-
 23°C Homo sapiens 8-methoxy-4-methylquinolin-2(1H)-one
0.0293
-
 23°C Homo sapiens 7,8-dimethoxy-4-methylquinolin-2(1H)-one
0.0541
-
 23°C Homo sapiens 6-methoxy-9-methyl-[1,3]dioxolo[4,5-h]quinolin-8(9H)-one