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Literature summary for 1.10.5.1 extracted from
- Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2 (2008), Biochem. J., 413, 81-91.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| the crystal structure of melatonin and 2-iodomelatonin in complex with quinone reductase 2 provide a detailed description of the enzyme active site that can now be utilized in the design of new and potent inhibitors of the enzyme, hanging-drop vapour-diffusion method | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-iodomelatonin | - |
Homo sapiens |  |
| 5-hydroxytryptamine | - |
Homo sapiens | |
| Melatonin | competitive inhibitor against N-methyldihydronicotinamide, uncompetitive against menadione. Melatonin and its analogues bind to and inhibit QR2 within the active site and not at an allosteric site | Homo sapiens | |
| N-acetyl-5-hydroxytryptamine | - |
Homo sapiens | |
| resveratrol | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P16083 | recombinant | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N-methyldihydronicotinamide + menadione | - |
Homo sapiens | N-methylnicotinamide + menadiol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MT3 | - |
Homo sapiens |
| QR2 | - |
Homo sapiens |
| quinone reductase 2 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
- |
Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
- |
Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0072 | - |
Melatonin | pH 8, 25°C, competitive inhibitor against N-methyldihydronicotinamide | Homo sapiens | |
| 0.092 | - |
Melatonin | pH 8, 25°C, uncompetitive against menadione | Homo sapiens | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00096 | - |
pH 8, 25°C | Homo sapiens | resveratrol | |
| 0.0011 | - |
pH 8, 25°C | Homo sapiens | 2-iodomelatonin | |
| 0.0099 | - |
pH 8, 25°C | Homo sapiens | N-acetyl-5-hydroxytryptamine | |
| 0.0113 | - |
pH 8, 25°C | Homo sapiens | Melatonin | |
| 0.0539 | - |
pH 8, 25°C | Homo sapiens | 5-hydroxytryptamine | |
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