Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of a chimeric enzyme of the human NQO2 with 43 amino acids from the carboxyl terminus of human DT-diaphorase. HNQO2-hDT43 still uses dihydronicotinamide riboside as an electron donor. The chimeric enzyme is inhibited by quercetin but not dicoumarol | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-hydroxyestradiol | 0.01 mM, 17% inhibition | Homo sapiens | |
4',5,7-trihydroxyflavone | 0.01 mM, 61% inhibition | Homo sapiens | |
4-hydroxyestradiol | 0.01 mM, 18% inhibition | Homo sapiens | |
4-hydroxyestrone | 0.01 mM, 22% inhibition | Homo sapiens | |
7,8-dihydroxyflavone | 0.01 mM, 7% inhibition | Homo sapiens | |
alpha-naphthoflavone | 0.01 mM, 75% inhibition | Homo sapiens | |
beta-naphthoflavone | 0.01 mM, 76% inhibition | Homo sapiens | |
chrysin | 0.01 mM, complete inhibition | Homo sapiens | |
dicoumarol | 0.01 mM, 25% inhibition | Homo sapiens | |
estradiol | 0.01 mM, 13% inhibition | Homo sapiens | |
flavone | 0.01 mM, 14% inhibition | Homo sapiens | |
galangin | 0.01 mM, complete inhibition | Homo sapiens | |
morin | 0.01 mM, 95% inhibition | Homo sapiens | |
quercetin | 0.01 mM, complete inhibition | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0023 | - |
menadione/3-(4,5-dimethylthiazaol-2-yl)-2,5-diphenyltetrazolium | - |
Homo sapiens | |
0.0047 | - |
Methyl red | - |
Homo sapiens | |
0.007 | - |
2,6-dichlorophenolindophenol | - |
Homo sapiens | |
0.012 | - |
3-(4,5-dimethylthiazaol-2-yl)-2,5-diphenyltetrazolium | - |
Homo sapiens | |
0.019 | - |
2,6-dichlorophenolindophenol | chimeric enzyme of the human NQO2 with 43 amino acids from the carboxyl terminus of human DT-diaphorase | Homo sapiens | |
0.028 | - |
dihydronicotinamide riboside | - |
Homo sapiens | |
0.252 | - |
NADH | - |
Homo sapiens | |
0.26 | - |
CB 1954 | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
26000 | - |
2 * 26000, SDS-PAGE | Homo sapiens |
50000 | - |
gel filtration | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dihydronicotinamide riboside + 2,6-dichlorophenolindophenol | - |
Homo sapiens | nicotinamide riboside + reduced 2,6-dichlorophenolindophenol | - |
? | |
dihydronicotinamide riboside + 3-(4,5-dimethylthiazaol-2-yl)-2,5-diphenyltetrazolium | - |
Homo sapiens | nicotinamide riboside + ? | - |
? | |
dihydronicotinamide riboside + CB 1954 | - |
Homo sapiens | nicotinamide riboside + ? | - |
? | |
dihydronicotinamide riboside + menadione/3-(4,5-dimethylthiazaol-2-yl)-2,5-diphenyltetrazolium | - |
Homo sapiens | nicotinamide riboside + ? | - |
? | |
dihydronicotinamide riboside + methyl red | - |
Homo sapiens | nicotinamide riboside + ? | - |
? | |
additional information | no activity with one-electron acceptors such as potassium ferricyanide | Homo sapiens | ? | - |
? | |
NADH + 2,6-dichlorophenolindophenol | - |
Homo sapiens | ? | - |
r |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 26000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
NQO2 | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
2.6 | - |
NADH | - |
Homo sapiens | |
3.83 | - |
Methyl red | - |
Homo sapiens | |
6 | - |
CB 1954 | - |
Homo sapiens | |
11 | - |
3-(4,5-dimethylthiazaol-2-yl)-2,5-diphenyltetrazolium | - |
Homo sapiens | |
38.33 | - |
menadione/3-(4,5-dimethylthiazaol-2-yl)-2,5-diphenyltetrazolium | - |
Homo sapiens | |
43.33 | - |
dihydronicotinamide riboside | - |
Homo sapiens | |
46.67 | - |
2,6-dichlorophenolindophenol | - |
Homo sapiens | |
91.8 | - |
2,6-dichlorophenolindophenol | chimeric enzyme of the human NQO2 with 43 amino acids from the carboxyl terminus of human DT-diaphorase | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | one prosthetic group per subunit | Homo sapiens | |
NADH | very poor electron donor | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000021 | - |
quercetin | - |
Homo sapiens |