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Literature summary for 1.10.3.1 extracted from
- Expression pattern and substrate specificity of Clonorchis sinensis tyrosinases (2013), Int. J. Parasitol., 43, 891-900.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli BL21(DE3) cells | Clonorchis sinensis |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| diethyldithiocarbamic acid | - |
Clonorchis sinensis |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.6 | 2 | L-Dopa | at pH 7.0 and 37°C | Clonorchis sinensis | |
| 23.52 | - |
catechol | at pH 7.0 and 37°C | Clonorchis sinensis | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| copper | contains copper | Clonorchis sinensis | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dihydroxyphenylalanine + O2 | Clonorchis sinensis | - |
dihydroxyphenylalanine quinone + H2O | - |
? | |
| L-tyrosine + O2 | Clonorchis sinensis | - |
dihydroxyphenylalanine + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Clonorchis sinensis | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | - |
Clonorchis sinensis |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Ni-NTA column chromatography | Clonorchis sinensis |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| egg | intrauterine immature egg | Clonorchis sinensis | - |
| vitelline gland | - |
Clonorchis sinensis | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-methylhydroquinone + O2 | low activity | Clonorchis sinensis | ? | - |
? | |
| 4-methylcatechol + O2 | highest activity | Clonorchis sinensis | ? | - |
? | |
| catechol + O2 | - |
Clonorchis sinensis | ? | - |
? | |
| dihydroxyphenylalanine + O2 | - |
Clonorchis sinensis | dihydroxyphenylalanine quinone + H2O | - |
? | |
| dopamine + O2 | - |
Clonorchis sinensis | ? | - |
? | |
| hydroquinone + O2 | low activity | Clonorchis sinensis | ? | - |
? | |
| L-DOPA + O2 | - |
Clonorchis sinensis | ? | - |
? | |
| L-tyrosine + O2 | - |
Clonorchis sinensis | dihydroxyphenylalanine + H2O | - |
? | |
| additional information | the enzyme shows minimal activity toward monophenol compounds such as tyramine, tyrosine and tyrosine methyl ester | Clonorchis sinensis | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TYR3 | isoform | Clonorchis sinensis |
| tyrosinase | - |
Clonorchis sinensis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| heme | - |
Clonorchis sinensis | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme is essential for Clonorchis sinensis reproduction | Clonorchis sinensis |
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