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Literature summary for 1.10.3.1 extracted from
- Kinetic study of monophenol and o-diphenol binding to oxytyrosinase (2005), J. Mol. Catal. B, 32, 185-192.
No PubMed abstract available
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | detailed kinetics, overview | Neurospora crassa | |
| additional information | - |
additional information | detailed kinetics, overview | Agaricus bisporus | |
| additional information | - |
additional information | detailed kinetics, overview | Streptomyces glaucescens | |
| 0.28 | - |
dopamine | - |
Neurospora crassa |  |
| 0.3 | - |
catechol | - |
Agaricus bisporus | |
| 0.38 | - |
D-Dopa | - |
Neurospora crassa | |
| 0.57 | - |
L-3,4-dihydroxyphenylalanine methyl ester | - |
Agaricus bisporus | |
| 0.74 | - |
chlorogenic acid | - |
Streptomyces glaucescens | |
| 0.8 | - |
L-Dopa | - |
Agaricus bisporus | |
| 0.91 | - |
tert-butylcatechol | - |
Streptomyces glaucescens | |
| 1.04 | - |
L-Dopa | - |
Neurospora crassa | |
| 1.05 | - |
3,4-dihydroxyphenyl propionic acid | - |
Streptomyces glaucescens | |
| 1.16 | - |
3,4-Dihydroxyphenyl acetic acid | - |
Streptomyces glaucescens | |
| 1.89 | - |
3,4-dihydroxyphenyl propionic acid | - |
Agaricus bisporus | |
| 1.9 | - |
4-methylcatechol | - |
Streptomyces glaucescens | |
| 2.16 | - |
1,2,3-benzenetriol | - |
Agaricus bisporus | |
| 2.2 | - |
dopamine | - |
Agaricus bisporus | |
| 2.36 | - |
4-methylcatechol | - |
Agaricus bisporus | |
| 2.8 | - |
tert-butylcatechol | - |
Agaricus bisporus | |
| 4.4 | - |
3,4-Dihydroxyphenyl acetic acid | - |
Neurospora crassa | |
| 4.5 | - |
catechol | - |
Streptomyces glaucescens | |
| 4.5 | - |
D-Dopa | - |
Agaricus bisporus | |
| 5.1 | - |
3,4-Dihydroxyphenyl acetic acid | - |
Agaricus bisporus | |
| 5.77 | - |
L-Dopa | - |
Streptomyces glaucescens | |
| 6.8 | - |
L-2-methyl-3,4-dihydroxyphenylalanine | - |
Agaricus bisporus | |
| 7.1 | - |
L-isoproterenol | - |
Agaricus bisporus | |
| 8 | - |
D-2-methyl-3,4-dihydroxyphenylalanine | - |
Agaricus bisporus | |
| 11.9 | - |
dopamine | - |
Streptomyces glaucescens | |
| 15.02 | - |
D-Dopa | - |
Streptomyces glaucescens | |
| 18.1 | - |
D-isoproterenol | - |
Agaricus bisporus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Cu2+ | copper enzyme | Neurospora crassa | |
| Cu2+ | copper enzyme | Agaricus bisporus | |
| Cu2+ | copper enzyme | Streptomyces glaucescens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Agaricus bisporus | - |
- |
- |
| Neurospora crassa | - |
- |
- |
| Streptomyces glaucescens | - |
- |
- |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Neurospora crassa |
| additional information | - |
- |
Agaricus bisporus |
| additional information | - |
- |
Streptomyces glaucescens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2 D-isoproterenol + O2 | - |
Agaricus bisporus | 2 4-[(1S)-1-hydroxy-2-[(propan-2-yl)amino]ethyl]cyclohexa-3,5-diene-1,2-dione + 2 H2O | - |
r | |
| 3,4-dihydroxyphenyl acetic acid + O2 | - |
Neurospora crassa | ? | - |
? | |
| 3,4-dihydroxyphenyl acetic acid + O2 | - |
Agaricus bisporus | ? | - |
? | |
| 3,4-dihydroxyphenyl acetic acid + O2 | - |
Streptomyces glaucescens | ? | - |
? | |
| 3,4-dihydroxyphenyl propionic acid + O2 | - |
Agaricus bisporus | ? | - |
r | |
| 3,4-dihydroxyphenyl propionic acid + O2 | - |
Streptomyces glaucescens | ? | - |
? | |
| 4-methylcatechol + O2 | - |
Agaricus bisporus | 4-methyl-1,2-benzoquinone + H2O | - |
? | |
| 4-methylcatechol + O2 | - |
Streptomyces glaucescens | 4-methyl-1,2-benzoquinone + H2O | - |
? | |
| 5-caffeoyl quinic acid + O2 | i.e. chlorogenic acid | Streptomyces glaucescens | ? | - |
? | |
| catechol + 1/2 O2 | - |
Agaricus bisporus | 1,2-benzoquinone + H2O | - |
? | |
| catechol + 1/2 O2 | - |
Streptomyces glaucescens | 1,2-benzoquinone + H2O | - |
? | |
| chlorogenic acid + O2 | - |
Streptomyces glaucescens | ? | - |
? | |
| D-2-methyl-3,4-dihydroxyphenylalanine + O2 | - |
Agaricus bisporus | 2-methyldopaquinone + H2O | - |
r | |
| D-dopa + 1/2 O2 | - |
Neurospora crassa | D-dopaquinone + H2O | - |
? | |
| D-dopa + 1/2 O2 | - |
Agaricus bisporus | D-dopaquinone + H2O | - |
? | |
| D-dopa + 1/2 O2 | - |
Streptomyces glaucescens | D-dopaquinone + H2O | - |
? | |
| D-isoproterenol + O2 | - |
Agaricus bisporus | ? | - |
? | |
| DL-2-methyl-3,4-dihydroxyphenylalanine + O2 | the L-isomer is preferred | Agaricus bisporus | 2-methyldopaquinone + H2O | - |
? | |
| DL-DOPA + O2 | i.e. DL-3,4-dihydroxyphenylalanine, the L-isomer is preferred | Neurospora crassa | dopaquinone + H2O | - |
? | |
| DL-DOPA + O2 | i.e. DL-3,4-dihydroxyphenylalanine, the L-isomer is preferred | Agaricus bisporus | dopaquinone + H2O | - |
? | |
| DL-DOPA + O2 | i.e. DL-3,4-dihydroxyphenylalanine, the L-isomer is preferred | Streptomyces glaucescens | dopaquinone + H2O | - |
? | |
| DL-isoproterenol + O2 | the L-isomer is preferred | Agaricus bisporus | ? | - |
? | |
| dopamine + O2 | - |
Neurospora crassa | ? | - |
? | |
| dopamine + O2 | - |
Agaricus bisporus | ? | - |
? | |
| dopamine + O2 | - |
Streptomyces glaucescens | ? | - |
? | |
| L-2-methyl-3,4-dihydroxyphenylalanine + O2 | - |
Agaricus bisporus | 2-methyldopaquinone + H2O | - |
r | |
| L-3,4-dihydroxyphenylalanine methyl ester + 1/2 O2 | - |
Agaricus bisporus | L-dopaquinone methyl ester + H2O | - |
? | |
| L-tyrosine + L-dopa + O2 | - |
Neurospora crassa | L-dopa + dopaquinone + H2O | - |
? | |
| L-tyrosine + L-dopa + O2 | - |
Streptomyces glaucescens | L-dopa + dopaquinone + H2O | - |
? | |
| additional information | the enzyme catalyzes the hydroxylation of monophenols to o-diphenols, monophenolase activity EC 1.14.18.1, and the oxidation of the o-diphenols to o-quinones, diphenolase activity EC 1.10.3.1, cross-reaction analysis, overview | Neurospora crassa | ? | - |
? | |
| additional information | the enzyme catalyzes the hydroxylation of monophenols to o-diphenols, monophenolase activity EC 1.14.18.1, and the oxidation of the o-diphenols to o-quinones, diphenolase activity EC 1.10.3.1, cross-reaction analysis, overview | Agaricus bisporus | ? | - |
? | |
| additional information | the enzyme catalyzes the hydroxylation of monophenols to o-diphenols, monophenolase activity EC 1.14.18.1, and the oxidation of the o-diphenols to o-quinones, diphenolase activity EC 1.10.3.1, cross-reaction analysis, overview | Streptomyces glaucescens | ? | - |
? | |
| pyrogallol + O2 | - |
Agaricus bisporus | ? | - |
? | |
| tert-butylcatechol + O2 | - |
Agaricus bisporus | ? | - |
? | |
| tert-butylcatechol + O2 | - |
Streptomyces glaucescens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| mettyrosinase | - |
Neurospora crassa |
| mettyrosinase | - |
Agaricus bisporus |
| mettyrosinase | - |
Streptomyces glaucescens |
| More | cf. 1.14.18.1 | Neurospora crassa |
| More | cf. 1.14.18.1 | Agaricus bisporus |
| More | cf. EC 1.14.18.1 | Streptomyces glaucescens |
| o-diphenolase | - |
Neurospora crassa |
| o-diphenolase | - |
Agaricus bisporus |
| o-diphenolase | - |
Streptomyces glaucescens |
| oxytyrosinase | - |
Neurospora crassa |
| oxytyrosinase | - |
Agaricus bisporus |
| oxytyrosinase | - |
Streptomyces glaucescens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 29.4 | - |
L-isoproterenol | - |
Agaricus bisporus | |
| 29.8 | - |
D-isoproterenol | - |
Agaricus bisporus | |
| 35.5 | - |
L-3,4-dihydroxyphenylalanine methyl ester | - |
Agaricus bisporus | |
| 44.3 | - |
L-2-methyl-3,4-dihydroxyphenylalanine | - |
Agaricus bisporus | |
| 44.3 | - |
D-2-methyl-3,4-dihydroxyphenylalanine | - |
Agaricus bisporus | |
| 107.4 | - |
L-Dopa | - |
Agaricus bisporus | |
| 107.4 | - |
D-Dopa | - |
Agaricus bisporus | |
| 142 | - |
3,4-Dihydroxyphenyl acetic acid | - |
Streptomyces glaucescens | |
| 184 | - |
D-Dopa | - |
Streptomyces glaucescens | |
| 340 | - |
D-Dopa | - |
Neurospora crassa | |
| 395 | - |
catechol | - |
Streptomyces glaucescens | |
| 439 | - |
dopamine | - |
Agaricus bisporus | |
| 533 | - |
3,4-Dihydroxyphenyl acetic acid | - |
Agaricus bisporus | |
| 553.5 | - |
3,4-dihydroxyphenyl propionic acid | - |
Agaricus bisporus | |
| 631.6 | - |
3,4-Dihydroxyphenyl acetic acid | - |
Agaricus bisporus | |
| 641.8 | - |
tert-butylcatechol | - |
Agaricus bisporus | |
| 785 | - |
chlorogenic acid | - |
Streptomyces glaucescens | |
| 841.6 | - |
4-methylcatechol | - |
Agaricus bisporus | |
| 850 | - |
3,4-Dihydroxyphenyl acetic acid | - |
Neurospora crassa | |
| 875 | - |
dopamine | - |
Streptomyces glaucescens | |
| 877.6 | - |
catechol | - |
Agaricus bisporus | |
| 1070 | - |
L-Dopa | - |
Neurospora crassa | |
| 1263 | - |
1,2,3-benzenetriol | - |
Agaricus bisporus | |
| 1350 | - |
dopamine | - |
Neurospora crassa | |
| 1445 | - |
L-Dopa | - |
Streptomyces glaucescens | |
| 1830 | - |
3,4-dihydroxyphenyl propionic acid | - |
Streptomyces glaucescens | |
| 2340 | - |
4-methylcatechol | - |
Streptomyces glaucescens | |
| 3320 | - |
tert-butylcatechol | - |
Streptomyces glaucescens | |
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