Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.10.3.1 extracted from

  • Khan, K.M.; Mughal, U.R.; Khan, M.T.H.; Perveen, Z.U.S.; Choudhary, M.I.
    Oxazolones: new tyrosinase inhibitors; synthesis and their structure-activity relationships (2006), Bioorg. Med. Chem., 14, 6027-6033.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-methyl-4-[(E)-(4-nitrophenyl)methylidene]-1,3-oxazol-5(4H)-one IC50: 0.00351 mM Agaricus bisporus
2-methyl-4-[(E)-2-thienylmethylidene]-1,3-oxazol-5-one IC50: 0.00311 mM Agaricus bisporus
2-methyl-4-[(E,2Z)-3-phenyl-2-propenyliden]-1,3-oxazol-5(4H)-one IC50: 0.00123 mM Agaricus bisporus
3-(acetoyloxy)-2-hydroxy-4-[[5-oxo-2-phenyl-1,3-oxazol-4(5H)-ylidene]methyl]phenylacetate IC50: 0.00215 mM Agaricus bisporus
4-[(E)-(4-nitrophenyl)methylidene]-2-phenyl-1,3-oxazol-5(4H)-one IC50: 0.00323 mM Agaricus bisporus
kojic acid IC50: 0.016.67 mM Agaricus bisporus
L-mimosine IC50: 0.00368 mM Agaricus bisporus
additional information synthesis and inhibitory potential of seventeen synthesized oxazolone derivatives, structure-activity relationships, overview Agaricus bisporus

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ copper-containing enzyme Agaricus bisporus

Organism

Organism UniProt Comment Textmining
Agaricus bisporus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
Agaricus bisporus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-dopa + 1/2 O2
-
Agaricus bisporus L-dopaquinone + H2O
-
?
additional information multifunctional enzyme Agaricus bisporus ?
-
?

Synonyms

Synonyms Comment Organism
More cf. 1.14.18.1 Agaricus bisporus
tyrosinase
-
Agaricus bisporus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00123
-
IC50: 0.00123 mM Agaricus bisporus 2-methyl-4-[(E,2Z)-3-phenyl-2-propenyliden]-1,3-oxazol-5(4H)-one
0.00215
-
IC50: 0.00215 mM Agaricus bisporus 3-(acetoyloxy)-2-hydroxy-4-[[5-oxo-2-phenyl-1,3-oxazol-4(5H)-ylidene]methyl]phenylacetate
0.00311
-
IC50: 0.00311 mM Agaricus bisporus 2-methyl-4-[(E)-2-thienylmethylidene]-1,3-oxazol-5-one
0.00323
-
IC50: 0.00323 mM Agaricus bisporus 4-[(E)-(4-nitrophenyl)methylidene]-2-phenyl-1,3-oxazol-5(4H)-one
0.00351
-
IC50: 0.00351 mM Agaricus bisporus 2-methyl-4-[(E)-(4-nitrophenyl)methylidene]-1,3-oxazol-5(4H)-one
0.00368
-
IC50: 0.00368 mM Agaricus bisporus L-mimosine
0.016
-
IC50: 0.016.67 mM Agaricus bisporus kojic acid