Literature summary for 1.1.99.39 extracted from

Lin, A.P.; Abbas, S.; Kim, S.W.; Ortega, M.; Bouamar, H.; Escobedo, Y.; Varadarajan, P.; Qin, Y.; Sudderth, J.; Schulz, E.; Deutsch, A.; Mohan, S.; Ulz, P.; Neumeister, P.; Rakheja, D.; Gao, X.; Hinck, A.; Weintraub, S.T.; DeBerardinis, R.J.; Sill, H.; Dahia, P.L.; Aguiar, R.C.
D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2 (2015), Nat. Commun., 6, 7768.

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Protein Variants

Protein Variants	Comment	Organism
A208T	inactive	Homo sapiens
A426T	inactive	Homo sapiens
G131X	inactive	Homo sapiens
R212W	inactive	Homo sapiens
R421H	inactive	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Homo sapiens	5739	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
(R)-2-hydroxyglutarate + acceptor	Homo sapiens	-	2-oxoglutarate + reduced acceptor	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q8N465	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEK-293 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(R)-2-hydroxyglutarate + acceptor	-	Homo sapiens	2-oxoglutarate + reduced acceptor	-	?

Synonyms

Synonyms	Comment	Organism
D2-hydroxyglutarate dehydrogenase	-	Homo sapiens
D2HGDH	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
FAD	-	Homo sapiens

General Information

General Information	Comment	Organism
metabolism	the enzyme elevates 2-oxoglutarate levels, influencing histone and DNA methylation, and HIF1alpha hydroxylation, and induces mitochondrial isocitrate dehydrogenase activity	Homo sapiens

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Release 2023.1 (January 2023)