Literature summary for 1.1.99.2 extracted from

Achouri, Y.; Noel, G.; Vertommen, D.; Rider, M.H.; Veiga-da-Cunha, M.; van Schaftingen, E.
Identification of a dehydrogenase acting on D-2-hydroxyglutarate (2004), Biochem. J., 381, 35-42.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
(S)-2-hydroxyglutarate + acceptor	Rattus norvegicus	enzyme deficiency might be the cause of L-2-hydroxyglutaric aciduria	2-oxoglutarate + reduced acceptor	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
enzyme separated from D-2-hydroxyglutarate dehydrogenase by chromatography on DEAE-sepharose	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(S)-2-hydroxyglutarate + acceptor	-	Rattus norvegicus	2-oxoglutarate + reduced acceptor	-	?
(S)-2-hydroxyglutarate + acceptor	enzyme deficiency might be the cause of L-2-hydroxyglutaric aciduria	Rattus norvegicus	2-oxoglutarate + reduced acceptor	-	?

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Release 2023.1 (January 2023)