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Literature summary for 1.1.99.2 extracted from

  • Jansen, G.A.; Wanders, R.J.A.
    L-2-Hydroxyglutarate dehydrogenase: identification of a novel enzyme activity in rat and human liver. Implications for L-2-hydroxyglutaric acidemia (1993), Biochim. Biophys. Acta, 1225, 53-56.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Rattus norvegicus 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-2-hydroxyglutarate + NAD+
-
Homo sapiens 2-oxoglutarate + NADH + H+
-
?
(S)-2-hydroxyglutarate + NAD+
-
Rattus norvegicus 2-oxoglutarate + NADH + H+
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.3 9.3 active over a wide pH range, without a clear optimum Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
7.3 9.3 active over a wide pH range, without a clear optimum Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens
NAD+
-
Rattus norvegicus