Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrial membrane | - |
Mus musculus | 31966 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Mus musculus | - |
kidney | highest activity | Mus musculus | - |
liver | highest activity | Mus musculus | - |
additional information | almost no activity is detected in brain and skeletal muscle | Mus musculus | - |
testis | highest activity | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
choline + acceptor | - |
Mus musculus | betaine aldehyde + reduced acceptor | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CHDH | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | liver samples from Chdh-deficient mice have 37% of the CHDH activity measured in wild type samples | down |
General Information | Comment | Organism |
---|---|---|
malfunction | deletion of choline dehydrogenase results in diminished sperm motility with abnormal mitochondrial morphology, but does not affect fetal viability or alter growth or liver, kidney, or muscle function. Loss of choline dehydrogenase activity results in decreased testicular betaine and increased choline and phosphocholine concentrations. Mitochondrial changes are also detected in liver, kidney, heart, and testis tissues. Chdh-deficient mice have increased plasma total homocysteine | Mus musculus |