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Literature summary for 1.1.98.7 extracted from

  • Szameit, C.; Miech, C.; Balleininger, M.; Schmidt, B.; von Figura, K.; Dierks, T.
    The iron sulfur protein AtsB is required for posttranslational formation of formylglycine in the Klebsiella sulfatase (1999), J. Biol. Chem., 274, 15375-15381 .
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in inactive form in Escherichia coli transformed with the structural gene atsA Klebsiella pneumoniae

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Klebsiella pneumoniae 5829
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + a [Klebsiella pneumoniae sulfatase]-L-serine Klebsiella pneumoniae the atsB gene product plays a posttranslational role that is essential for the sulfatase to gain its catalytic activity [Klebsiella pneumoniae sulfatase]-3-oxo-L-alanine + 5'-deoxyadenosine + L-methionine
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 ?

Organism

Organism UniProt Comment Textmining
Klebsiella pneumoniae Q9X758
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + a [Klebsiella pneumoniae sulfatase]-L-serine the atsB gene product plays a posttranslational role that is essential for the sulfatase to gain its catalytic activity Klebsiella pneumoniae [Klebsiella pneumoniae sulfatase]-3-oxo-L-alanine + 5'-deoxyadenosine + L-methionine
-
 ?
S-adenosyl-L-methionine + [Klebsiella pneumoniae sulfatase]-L-serine peptide analysis of the Klebsiella pneumoniae sulfatase protein expressed in the presence of AtsB reveales that half of the polypeptides carry the formylglycine at position 72, while the remaining polypeptides carry the encoded serine. The inactive sulfatase expressed in the absence of AtsB carries exclusively serine 72, demonstrating that the atsB gene is required for formylglycine modification Klebsiella pneumoniae [Klebsiella pneumoniae sulfatase]-3-oxo-L-alanine + 5'-deoxyadenosine + L-methionine
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 ?

Synonyms

Synonyms Comment Organism
AtsB
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 Klebsiella pneumoniae

Cofactor

Cofactor Comment Organism Structure
Fe-S center
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 Klebsiella pneumoniae