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Literature summary for 1.1.98.7 extracted from

  • Benjdia, A.; Subramanian, S-; Leprince, J.; Vaudry, H.; Johnson, M.K.; Berteau, O.
    Anaerobic sulfatase-maturating enzyme--a mechanistic link with glycyl radical-activating enzymes (2010), FEBS J., 277, 1906-1920.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.98.7

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) Clostridium perfringens

Metals/Ions

Metals/Ions Comment Organism Structure
[4Fe-4S]2+ cluster three [4Fe-4S]2+ clusters per enzyme molecule Clostridium perfringens

Organism

Organism UniProt Comment Textmining
Clostridium perfringens Q8XMQ3
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-
Clostridium perfringens type A Q8XMQ3
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-

Purification (Commentary)

Purification (Comment) Organism
-
 Clostridium perfringens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ac-AVPSSIPSRASILTGM-NH2 + S-adenosyl-L-methionine + dithionite a flavodoxin/flavodoxin reductase/NADPH system may substitute for dithionite Clostridium perfringens Ac-AVPS-3-oxo-L-Ala-IPSRASILTGM-NH2 + L-methionine + 5'-deoxyadenosine + sulfur dioxide + H2O
-
 ?
Ac-AVPSSIPSRASILTGM-NH2 + S-adenosyl-L-methionine + dithionite a flavodoxin/flavodoxin reductase/NADPH system may substitute for dithionite Clostridium perfringens type A Ac-AVPS-3-oxo-L-Ala-IPSRASILTGM-NH2 + L-methionine + 5'-deoxyadenosine + sulfur dioxide + H2O
-
 ?
additional information the enzme also perfoms the reaction of the Cys-type anaerobic sulfatase-maturating enzyme, converting a cysteine residue of sulfatase into a 3-oxo-L-alanine residue. The post-translational modification of sulfatases, i.e. the creation of a 3-oxo-L-alanine (i.e. Calpha-formylglycine) residue from a cysteine or serine is vital for the proper function of sulfatases Clostridium perfringens ?
-
 ?
additional information the enzme also perfoms the reaction of the Cys-type anaerobic sulfatase-maturating enzyme, converting a cysteine residue of sulfatase into a 3-oxo-L-alanine residue. The post-translational modification of sulfatases, i.e. the creation of a 3-oxo-L-alanine (i.e. Calpha-formylglycine) residue from a cysteine or serine is vital for the proper function of sulfatases Clostridium perfringens type A ?
-
 ?

Synonyms

Synonyms Comment Organism
anaerobic sulfatase-maturating enzyme
-
 Clostridium perfringens
nSMEcpe
-
 Clostridium perfringens

General Information

General Information Comment Organism
metabolism involved in the pathway of sulfatase oxidation Clostridium perfringens