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Literature summary for 1.1.98.6 extracted from
- Allosteric control of the substrate specificity of the anaerobic ribonucleotide reductase from Escherichia coli (1994), J. Biol. Chem., 269, 26052-26057.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| dATP | - |
Escherichia coli |  |
| dTTP | - |
Escherichia coli | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.05 | - |
CTP | presence of ATP, pH not specified in the publication, temperature not specified in the publication | Escherichia coli | |
| 0.06 | - |
GTP | presence of dTTP, pH not specified in the publication, temperature not specified in the publication | Escherichia coli | |
| 0.4 | - |
GTP | presence of dTTP, pH not specified in the publication, temperature not specified in the publication | Escherichia coli | |
| 0.5 | - |
CTP | presence of ATP, pH not specified in the publication, temperature not specified in the publication | Escherichia coli | |
| 1 | - |
UTP | presence of ATP, pH not specified in the publication, temperature not specified in the publication | Escherichia coli | |
| 4 | - |
ATP | presence of dGTP, pH not specified in the publication, temperature not specified in the publication | Escherichia coli | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + formate | - |
Escherichia coli | dATP + CO2 + H2O | - |
? | |
| CTP + formate | - |
Escherichia coli | dCTP + CO2 + H2O | - |
? | |
| GTP + formate | - |
Escherichia coli | dGTP + CO2 + H2O | - |
? | |
| additional information | the enzyme reduces ribonucleotides at a low basal rate. Reduction is stimulated up to 10fold by an appropriate modulator (dGTP for ATP reduction, ATP for CTP and UTP reduction, and dlTP for GTP reduction). The enzyme has one class of sites that binds ATP and dATP and regulates pyrimidine ribonucleotide reduction, and another class that binds dATP, dGTP, and dTTP and regulates purine ribonucleotide reduction | Escherichia coli | ? | - |
? | |
| UTP + formate | - |
Escherichia coli | dUTP + CO2 + H2O | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.012 | - |
dATP | substrate ATP, pH not specified in the publication, temperature not specified in the publication | Escherichia coli | |
| 0.05 | - |
dTTP | substrate GTP, pH not specified in the publication, temperature not specified in the publication | Escherichia coli | |
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