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Literature summary for 1.1.5.B3 extracted from
- Regulation of L-lactate utilization by the FadR-type regulator LldR of Corynebacterium glutamicum (2008), J. Bacteriol., 190, 963-971.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | overexpression of the regulator gene lldR results in strongly reduced NCgl2816-lldD mRNA levels and strongly reduced LldD activity, and as a consequence, in a severe growth defect was observed in cells grown on L-lactate as the sole carbon and energy source, but not in cells grown on glucose, ribose, or acetate. Deletion of lldR has no effect on growth on these carbon sources but results in high NCgl2816-lldD mRNA levels and high LldD activity in the presence and absence of L-lactate, overview | Corynebacterium glutamicum |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | the enzyme expression is supressed/regulated by the FadR-type regulator LldR, encoded by NCgl2814, binds to the upstream region of NCgl2816-lldD, L-lactate prevents binding of LldRHis to the NCgl2816-lldD promoter region | Corynebacterium glutamicum |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-lactate + oxidized 2,6-dichlorophenolindophenol | Corynebacterium glutamicum | - |
pyruvate + reduced 2,6-dichlorophenolindophenol | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Corynebacterium glutamicum | - |
gene lldD | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Corynebacterium glutamicum |
| 0.14 | - |
wild-type strain, cell extract | Corynebacterium glutamicum |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-lactate + oxidized 2,6-dichlorophenolindophenol | - |
Corynebacterium glutamicum | pyruvate + reduced 2,6-dichlorophenolindophenol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| LldD | - |
Corynebacterium glutamicum |
| quinone-dependent L-lactate dehydrogenase | - |
Corynebacterium glutamicum |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Corynebacterium glutamicum |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Corynebacterium glutamicum |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| 2,6-dichlorophenolindophenol | - |
Corynebacterium glutamicum | |
| quinone | dependent on | Corynebacterium glutamicum | |
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