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Literature summary for 1.1.5.3 extracted from
- Calcium activation of mitochondrial glycerol phosphate dehydrogenase restudied (1996), Arch. Biochem. Biophys., 326, 79-84.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.4 | - |
glycerol 3-phosphate | enzyme from testis and pancreatic islets, in presence of saturating concentrations of free Ca2+ | Rattus norvegicus |  |
| 2.5 | - |
glycerol 3-phosphate | enzyme from pancreatic islets, in absence of free calcium | Rattus norvegicus | |
| 3.2 | - |
glycerol 3-phosphate | enzyme from testis in absence of free calcium | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | inner mitochondrial membrane. The mature protein has three transmembrane helices. The first membrane-spanning region coincides with the FAD site and thus this site is placed within the membrane. The calcium-binding region lies outside the membrane exposed to the cytosolic environment | Rattus norvegicus | 5739 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | activates | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| sn-glycerol 3-phosphate + acceptor | Rattus norvegicus | key enzyme of the glycerol phosphate shuttle | glycerone phosphate + reduced acceptor | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| pancreas | - |
Rattus norvegicus | - |
| testis | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| sn-glycerol 3-phosphate + acceptor | key enzyme of the glycerol phosphate shuttle | Rattus norvegicus | glycerone phosphate + reduced acceptor | - |
? | |
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Release 2023.1 (January 2023)
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