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Literature summary for 1.1.3.46 extracted from

  • Hubbard, B.K.; Thomas, M.G.; Walsh, C.T.
    Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics (2000), Chem. Biol., 7, 931-942.
    View publication on PubMed
Search for more literature for 1.1.3.46

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Amycolatopsis orientalis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-2-hydroxy-2-(4-hydroxyphenyl)acetate + O2 Amycolatopsis orientalis (S)-2-hydroxy-2-(4-hydroxyphenyl)acetate i.e. (S)-4-hydroxymandelate. The enzyme is involed in the biosynthesis of the non-proteinogenic amino acid (S)-4-hydroxyphenylglycine a constituent of peptide antibiotics 2-(4-hydroxyphenyl)-2-oxoacetate + H2O2 2-(4-hydroxyphenyl)-2-oxoacetate i.e. 4-hydroxyphenylglyoxylate ?

Organism

Organism UniProt Comment Textmining
Amycolatopsis orientalis G4V4S8
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Amycolatopsis orientalis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-2-hydroxy-2-(4-hydroxyphenyl)acetate + O2 (S)-2-hydroxy-2-(4-hydroxyphenyl)acetate i.e. (S)-4-hydroxymandelate. The enzyme is involed in the biosynthesis of the non-proteinogenic amino acid (S)-4-hydroxyphenylglycine a constituent of peptide antibiotics Amycolatopsis orientalis 2-(4-hydroxyphenyl)-2-oxoacetate + H2O2 2-(4-hydroxyphenyl)-2-oxoacetate i.e. 4-hydroxyphenylglyoxylate ?

Synonyms

Synonyms Comment Organism
HmO
-
 Amycolatopsis orientalis
p-hydroxymandelate oxidase
-
 Amycolatopsis orientalis

Cofactor

Cofactor Comment Organism Structure
FMN
-
 Amycolatopsis orientalis