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Literature summary for 1.1.3.38 extracted from

  • Gygli, G.; Lucas, M.F.; Guallar, V.; van Berkel, W.J.H.
    The ins and outs of vanillyl alcohol oxidase Identification of ligand migration paths (2017), PLoS Comput. Biol., 13, e1005787 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.3.38

Organism

Organism UniProt Comment Textmining
Penicillium simplicissimum P56216
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
creosol + O2
-
 Penicillium simplicissimum vanillin + H2O
-
 ?
vanillyl alcohol + O2
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 Penicillium simplicissimum vanillin + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
VAO
-
 Penicillium simplicissimum

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Penicillium simplicissimum

General Information

General Information Comment Organism
metabolism identification of a gated entry and exit path at the subunit interface of VAO for small phenolic ligands. The residues Met192, Met195 and Glu464 form a portal in this path. Residues His466 and Tyr503 act as concierges, obstructing the path to the active site for phenolic substrates once substrate is bound. An additional, different entry and exit path for dioxygen and hydrogen peroxide at the interface of the two domains of VAO exists. Tyr51 in this path could assist reduced flavin oxidation in VAO Penicillium simplicissimum