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Literature summary for 1.1.3.15 extracted from

  • Dutta, C.; Avitahl-Curtis, N.; Pursell, N.; Larsson Cohen, M.; Holmes, B.; Diwanji, R.; Zhou, W.; Apponi, L.; Koser, M.; Ying, B.; Chen, D.; Shui, X.; Saxena, U.; Cyr, W.A.; Shah, A.; Nazef, N.; Wang, W.; Abrams, M.; Dudek, H.; Salido, E.; Brown, B.D.; Lai, C.
    Inhibition of glycolate oxidase with dicer-substrate siRNA reduces calcium oxalate deposition in a mouse model of primary hyperoxaluria type 1 (2016), Mol. Ther., 24, 770-778 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.3.15

Cloned(Commentary)

Cloned (Comment) Organism
gene HAO1, quantitative real-time PCR enzyme expression analysis Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information enzyme knockout by Dicer-substrate small interfering RNAs (DsiRNAs) targeting hydroxyacid oxidase 1 (HAO1) mRNA, relationship of Hao1 mRNA and glycolate oxidase protein knockdown to oxalate reduction, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
peroxisome
-
 Mus musculus 5777
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
an (S)-2-hydroxy carboxylate + O2 Mus musculus
-
 a 2-oxo carboxylate + H2O2
-
 ?
an (S)-2-hydroxy carboxylate + O2 Mus musculus C57BL/6
-
 a 2-oxo carboxylate + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9WU19
-
-
Mus musculus C57BL/6 Q9WU19
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Mus musculus
-
liver
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
an (S)-2-hydroxy carboxylate + O2
-
 Mus musculus a 2-oxo carboxylate + H2O2
-
 ?
an (S)-2-hydroxy carboxylate + O2
-
 Mus musculus C57BL/6 a 2-oxo carboxylate + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
glycolate oxidase
-
 Mus musculus
HAO1
-
 Mus musculus
hydroxyacid oxidase 1
-
 Mus musculus

General Information

General Information Comment Organism
malfunction an alternative approach to prevent glyoxylate production in subjects with primary hyperoxaluria type 1 (PH1) is using Dicer-substrate small interfering RNAs (DsiRNAs) targeting hydroxyacid oxidase 1 (HAO1) mRNA, which encodes glycolate oxidase (GO), to reduce the hepatic conversion of glycolate to glyoxylate. This approach efficiently reduces GO mRNA and protein in the livers of mice. Reduction of hepatic GO leads to normalization of urine oxalate levels and reduces CaOx deposition in a preclinical mouse model of PH1. Hao1-/- mice show elevated levels of urinary glycolate without renal damage or other phenotypic consequences Mus musculus