Literature summary for 1.1.3.15 extracted from

Barawkar, D.A.; Bandyopadhyay, A.; Deshpande, A.; Koul, S.; Kandalkar, S.; Patil, P.; Khose, G.; Vyas, S.; Mone, M.; Bhosale, S.; Singh, U.; De, S.; Meru, A.; Gundu, J.; Chugh, A.; Palle, V.P.; Mookhtiar, K.A.; Vacca, J.P.; Chakravarty, P.K.; Nargund, R.P.; Wright, S.D.; Roy, S.; Graziano, M.P.; Cully, D.; Ca, C.a.i.
Discovery of pyrazole carboxylic acids as potent inhibitors of rat long chain L-2-hydroxy acid oxidase (2012), Bioorg. Med. Chem. Lett., 22, 4341-4347.

Inhibitors

Inhibitors	Comment	Organism
3-benzyl-4-[[4-(4-fluorophenyl)pyridin-2-yl]methyl]-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
3-benzyl-4-[[4-(4-fluorophenyl)pyridin-2-yl]methyl]-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
3-ethoxy-4-[[4-(4-fluorophenyl)pyridin-2-yl]methyl]-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
3-ethoxy-4-[[4-(4-fluorophenyl)pyridin-2-yl]methyl]-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
3-ethyl-4-[[4-(4-fluorophenyl)pyridin-2-yl]methyl]-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
3-ethyl-4-[[4-(4-fluorophenyl)pyridin-2-yl]methyl]-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
3-methyl-4-(2-phenoxybenzyl)-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
3-methyl-4-(2-phenoxybenzyl)-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
3-methyl-4-(2-phenylethyl)-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
3-methyl-4-(3-phenoxybenzyl)-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
3-methyl-4-(3-phenoxybenzyl)-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
3-methyl-4-(4-phenoxybenzyl)-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
3-methyl-4-(4-phenoxybenzyl)-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
3-methyl-4-(naphthalen-1-ylmethyl)-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
3-methyl-4-(naphthalen-1-ylmethyl)-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
3-methyl-4-(naphthalen-2-ylmethyl)-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
3-methyl-4-(naphthalen-2-ylmethyl)-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
3-methyl-4-(quinolin-2-ylmethyl)-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
3-methyl-4-(quinolin-2-ylmethyl)-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
3-methyl-4-[2-(trifluoromethoxy)benzyl]-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
3-methyl-4-[2-(trifluoromethoxy)benzyl]-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
3-methyl-4-[2-(trifluoromethyl)benzyl]-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
3-methyl-4-[2-(trifluoromethyl)benzyl]-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
3-methyl-4-[3-(pyridin-3-yl)benzyl]-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
3-methyl-4-[3-(pyridin-3-yl)benzyl]-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
3-methyl-4-[3-(pyridin-4-yl)benzyl]-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
3-methyl-4-[3-(pyridin-4-yl)benzyl]-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
3-methyl-4-[3-(trifluoromethyl)benzyl]-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
3-methyl-4-[3-(trifluoromethyl)benzyl]-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
3-methyl-4-[4-(trifluoromethoxy)benzyl]-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
3-methyl-4-[4-(trifluoromethoxy)benzyl]-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
3-methyl-4-[4-(trifluoromethyl)benzyl]-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
3-methyl-4-[4-(trifluoromethyl)benzyl]-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
3-methyl-4-[[4'-(trifluoromethoxy)biphenyl-3-yl]methyl]-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
3-methyl-4-[[4'-(trifluoromethoxy)biphenyl-3-yl]methyl]-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
3-methyl-4-[[4'-(trifluoromethoxy)biphenyl-4-yl]methyl]-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
3-methyl-4-[[4'-(trifluoromethoxy)biphenyl-4-yl]methyl]-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
3-methyl-4-[[4'-(trifluoromethyl)biphenyl-3-yl]methyl]-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
3-methyl-4-[[4'-(trifluoromethyl)biphenyl-3-yl]methyl]-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
3-methyl-4-[[4'-(trifluoromethyl)biphenyl-4-yl]methyl]-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
3-methyl-4-[[4'-(trifluoromethyl)biphenyl-4-yl]methyl]-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
4-(1-benzofuran-2-ylmethyl)-3-methyl-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
4-(1-benzofuran-2-ylmethyl)-3-methyl-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
4-(1-benzothiophen-2-ylmethyl)-3-methyl-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
4-(1-benzothiophen-2-ylmethyl)-3-methyl-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
4-(3-carbamoylbenzyl)-3-methyl-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
4-(3-carbamoylbenzyl)-3-methyl-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
4-(3-carboxybenzyl)-3-methyl-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
4-(3-carboxybenzyl)-3-methyl-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
4-(3-cyanobenzyl)-3-methyl-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
4-(3-cyanobenzyl)-3-methyl-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
4-(3-fluorobenzyl)-3-methyl-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
4-(3-fluorobenzyl)-3-methyl-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
4-(4'-fluorobiphenyl-3-yl)-3-methyl-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
4-(4'-fluorobiphenyl-3-yl)-3-methyl-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
4-(4'-fluorobiphenyl-4-yl)-3-methyl-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
4-(4'-fluorobiphenyl-4-yl)-3-methyl-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
4-(4-carbamoylbenzyl)-3-methyl-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
4-(4-carbamoylbenzyl)-3-methyl-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
4-(4-carboxybenzyl)-3-methyl-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
4-(4-carboxybenzyl)-3-methyl-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
4-(4-cyanobenzyl)-3-methyl-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
4-(4-cyanobenzyl)-3-methyl-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
4-(4-fluorobenzyl)-3-methyl-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
4-(4-fluorobenzyl)-3-methyl-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
4-(4-fluorophenyl)-3-methyl-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
4-(4-fluorophenyl)-3-methyl-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
4-[(2'-fluorobiphenyl-3-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
4-[(2'-fluorobiphenyl-3-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
4-[(3'-fluorobiphenyl-3-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
4-[(3'-fluorobiphenyl-3-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
4-[(4'-carbamoylbiphenyl-3-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
4-[(4'-carbamoylbiphenyl-3-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
4-[(4'-carboxybiphenyl-3-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
4-[(4'-carboxybiphenyl-3-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
4-[(4'-cyanobiphenyl-3-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
4-[(4'-cyanobiphenyl-3-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
4-[(4'-fluorobiphenyl-2-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
4-[(4'-fluorobiphenyl-2-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
4-[(4'-fluorobiphenyl-3-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
4-[(4'-fluorobiphenyl-3-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
4-[(4'-fluorobiphenyl-4-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
4-[(4'-fluorobiphenyl-4-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
4-[2-(4'-fluorobiphenyl-3-yl)ethyl]-3-methyl-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
4-[2-(4'-fluorobiphenyl-3-yl)ethyl]-3-methyl-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
4-[2-(4'-fluorobiphenyl-4-yl)ethyl]-3-methyl-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
4-[2-(4'-fluorobiphenyl-4-yl)ethyl]-3-methyl-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
4-[2-(4-fluorophenyl)ethyl]-3-methyl-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
4-[2-(4-fluorophenyl)ethyl]-3-methyl-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
4-[2-(biphenyl-4-yl)ethyl]-3-methyl-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
4-[[4'-(2-amino-2-oxoethyl)biphenyl-3-yl]methyl]-3-methyl-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
4-[[4'-(2-amino-2-oxoethyl)biphenyl-3-yl]methyl]-3-methyl-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
4-[[4-(4-fluorophenyl)pyridin-2-yl]methyl]-3-(2-phenylethyl)-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
4-[[4-(4-fluorophenyl)pyridin-2-yl]methyl]-3-(2-phenylethyl)-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
4-[[4-(4-fluorophenyl)pyridin-2-yl]methyl]-3-(propan-2-yl)-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
4-[[4-(4-fluorophenyl)pyridin-2-yl]methyl]-3-(propan-2-yl)-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
4-[[4-(4-fluorophenyl)pyridin-2-yl]methyl]-3-phenyl-1H-pyrazole-5-carboxylic acid	-	Homo sapiens
4-[[4-(4-fluorophenyl)pyridin-2-yl]methyl]-3-phenyl-1H-pyrazole-5-carboxylic acid	-	Rattus norvegicus
additional information	development of selective inhibitors of Hao2 from screening of a compound library, overview	Homo sapiens
additional information	development of selective inhibitors of Hao2 from screening of a compound library, overview	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
peroxisome	-	Homo sapiens	5777	-
peroxisome	-	Rattus norvegicus	5777	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
kidney	-	Homo sapiens	-
kidney	-	Rattus norvegicus	-
liver	-	Homo sapiens	-
liver	-	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
Hao2	-	Homo sapiens
Hao2	-	Rattus norvegicus
long chain L-2-hydroxy acid oxidase 2	-	Homo sapiens
long chain L-2-hydroxy acid oxidase 2	-	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
FMN	dependent on	Homo sapiens
FMN	dependent on	Rattus norvegicus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor
0.0002	-	pH and temperature not specified in the publication	Rattus norvegicus	4-(3-fluorobenzyl)-3-methyl-1H-pyrazole-5-carboxylic acid
0.0002	-	pH and temperature not specified in the publication	Rattus norvegicus	4-[(4'-carbamoylbiphenyl-3-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid
0.0002	-	pH and temperature not specified in the publication	Rattus norvegicus	3-methyl-4-(naphthalen-1-ylmethyl)-1H-pyrazole-5-carboxylic acid
0.0003	-	pH and temperature not specified in the publication	Rattus norvegicus	4-[(4'-fluorobiphenyl-3-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid
0.0003	-	pH and temperature not specified in the publication	Rattus norvegicus	4-(1-benzothiophen-2-ylmethyl)-3-methyl-1H-pyrazole-5-carboxylic acid
0.0003	-	pH and temperature not specified in the publication	Rattus norvegicus	3-methyl-4-[3-(trifluoromethyl)benzyl]-1H-pyrazole-5-carboxylic acid
0.0003	-	pH and temperature not specified in the publication	Rattus norvegicus	3-methyl-4-[[4'-(trifluoromethoxy)biphenyl-3-yl]methyl]-1H-pyrazole-5-carboxylic acid
0.0003	-	pH and temperature not specified in the publication	Rattus norvegicus	4-[(4'-cyanobiphenyl-3-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid
0.0003	-	pH and temperature not specified in the publication	Rattus norvegicus	3-methyl-4-[3-(pyridin-4-yl)benzyl]-1H-pyrazole-5-carboxylic acid
0.0003	-	pH and temperature not specified in the publication	Rattus norvegicus	3-ethyl-4-[[4-(4-fluorophenyl)pyridin-2-yl]methyl]-1H-pyrazole-5-carboxylic acid
0.0004	-	pH and temperature not specified in the publication	Rattus norvegicus	4-[(4'-fluorobiphenyl-4-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid
0.0004	-	pH and temperature not specified in the publication	Rattus norvegicus	3-methyl-4-[[4'-(trifluoromethyl)biphenyl-3-yl]methyl]-1H-pyrazole-5-carboxylic acid
0.0004	-	pH and temperature not specified in the publication	Rattus norvegicus	4-[[4'-(2-amino-2-oxoethyl)biphenyl-3-yl]methyl]-3-methyl-1H-pyrazole-5-carboxylic acid
0.0004	-	pH and temperature not specified in the publication	Rattus norvegicus	3-methyl-4-[3-(pyridin-3-yl)benzyl]-1H-pyrazole-5-carboxylic acid
0.0005	-	pH and temperature not specified in the publication	Rattus norvegicus	4-(3-cyanobenzyl)-3-methyl-1H-pyrazole-5-carboxylic acid
0.0005	-	pH and temperature not specified in the publication	Rattus norvegicus	4-[(3'-fluorobiphenyl-3-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid
0.0005	-	pH and temperature not specified in the publication	Rattus norvegicus	3-methyl-4-(4-phenoxybenzyl)-1H-pyrazole-5-carboxylic acid
0.0005	-	pH and temperature not specified in the publication	Rattus norvegicus	4-[[4-(4-fluorophenyl)pyridin-2-yl]methyl]-3-(propan-2-yl)-1H-pyrazole-5-carboxylic acid
0.0006	-	pH and temperature not specified in the publication	Homo sapiens	4-(4-cyanobenzyl)-3-methyl-1H-pyrazole-5-carboxylic acid
0.0006	-	pH and temperature not specified in the publication	Rattus norvegicus	3-methyl-4-(3-phenoxybenzyl)-1H-pyrazole-5-carboxylic acid
0.0007	-	pH and temperature not specified in the publication	Rattus norvegicus	4-(4-fluorobenzyl)-3-methyl-1H-pyrazole-5-carboxylic acid
0.0007	-	pH and temperature not specified in the publication	Rattus norvegicus	3-methyl-4-[2-(trifluoromethoxy)benzyl]-1H-pyrazole-5-carboxylic acid
0.0007	-	pH and temperature not specified in the publication	Rattus norvegicus	3-benzyl-4-[[4-(4-fluorophenyl)pyridin-2-yl]methyl]-1H-pyrazole-5-carboxylic acid
0.0008	-	pH and temperature not specified in the publication	Homo sapiens	4-(4-carbamoylbenzyl)-3-methyl-1H-pyrazole-5-carboxylic acid
0.0008	-	pH and temperature not specified in the publication	Rattus norvegicus	4-[[4-(4-fluorophenyl)pyridin-2-yl]methyl]-3-(2-phenylethyl)-1H-pyrazole-5-carboxylic acid
0.0009	-	pH and temperature not specified in the publication	Rattus norvegicus	4-[2-(4'-fluorobiphenyl-4-yl)ethyl]-3-methyl-1H-pyrazole-5-carboxylic acid
0.0009	-	pH and temperature not specified in the publication	Rattus norvegicus	4-[2-(4'-fluorobiphenyl-3-yl)ethyl]-3-methyl-1H-pyrazole-5-carboxylic acid
0.0009	-	pH and temperature not specified in the publication	Rattus norvegicus	4-(3-carbamoylbenzyl)-3-methyl-1H-pyrazole-5-carboxylic acid
0.0009	-	pH and temperature not specified in the publication	Rattus norvegicus	4-[(2'-fluorobiphenyl-3-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid
0.00091	-	pH and temperature not specified in the publication	Rattus norvegicus	4-[2-(biphenyl-4-yl)ethyl]-3-methyl-1H-pyrazole-5-carboxylic acid
0.00095	-	pH and temperature not specified in the publication	Homo sapiens	4-(4'-fluorobiphenyl-3-yl)-3-methyl-1H-pyrazole-5-carboxylic acid
0.0011	-	pH and temperature not specified in the publication	Rattus norvegicus	3-methyl-4-[[4'-(trifluoromethyl)biphenyl-4-yl]methyl]-1H-pyrazole-5-carboxylic acid
0.0011	-	pH and temperature not specified in the publication	Rattus norvegicus	4-[(4'-carboxybiphenyl-3-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid
0.0011	-	pH and temperature not specified in the publication	Rattus norvegicus	3-methyl-4-(naphthalen-2-ylmethyl)-1H-pyrazole-5-carboxylic acid
0.0011	-	pH and temperature not specified in the publication	Homo sapiens	4-[[4-(4-fluorophenyl)pyridin-2-yl]methyl]-3-phenyl-1H-pyrazole-5-carboxylic acid
0.00113	-	pH and temperature not specified in the publication	Homo sapiens	4-(3-fluorobenzyl)-3-methyl-1H-pyrazole-5-carboxylic acid
0.0012	-	pH and temperature not specified in the publication	Homo sapiens	3-ethoxy-4-[[4-(4-fluorophenyl)pyridin-2-yl]methyl]-1H-pyrazole-5-carboxylic acid
0.0012	-	pH and temperature not specified in the publication	Rattus norvegicus	3-ethoxy-4-[[4-(4-fluorophenyl)pyridin-2-yl]methyl]-1H-pyrazole-5-carboxylic acid
0.0013	-	pH and temperature not specified in the publication	Rattus norvegicus	3-methyl-4-[2-(trifluoromethyl)benzyl]-1H-pyrazole-5-carboxylic acid
0.0013	-	pH and temperature not specified in the publication	Rattus norvegicus	3-methyl-4-[4-(trifluoromethoxy)benzyl]-1H-pyrazole-5-carboxylic acid
0.00135	-	pH and temperature not specified in the publication	Rattus norvegicus	4-(4-fluorophenyl)-3-methyl-1H-pyrazole-5-carboxylic acid
0.0017	-	pH and temperature not specified in the publication	Rattus norvegicus	3-methyl-4-(quinolin-2-ylmethyl)-1H-pyrazole-5-carboxylic acid
0.0018	-	pH and temperature not specified in the publication	Rattus norvegicus	4-[[4-(4-fluorophenyl)pyridin-2-yl]methyl]-3-phenyl-1H-pyrazole-5-carboxylic acid
0.002	-	pH and temperature not specified in the publication	Rattus norvegicus	3-methyl-4-[[4'-(trifluoromethoxy)biphenyl-4-yl]methyl]-1H-pyrazole-5-carboxylic acid
0.0021	-	pH and temperature not specified in the publication	Homo sapiens	4-[[4-(4-fluorophenyl)pyridin-2-yl]methyl]-3-(propan-2-yl)-1H-pyrazole-5-carboxylic acid
0.0022	-	pH and temperature not specified in the publication	Homo sapiens	4-[[4'-(2-amino-2-oxoethyl)biphenyl-3-yl]methyl]-3-methyl-1H-pyrazole-5-carboxylic acid
0.0022	-	pH and temperature not specified in the publication	Homo sapiens	3-methyl-4-(quinolin-2-ylmethyl)-1H-pyrazole-5-carboxylic acid
0.0023	-	pH and temperature not specified in the publication	Homo sapiens	3-methyl-4-[2-(trifluoromethoxy)benzyl]-1H-pyrazole-5-carboxylic acid
0.003	-	pH and temperature not specified in the publication	Homo sapiens	4-(3-carboxybenzyl)-3-methyl-1H-pyrazole-5-carboxylic acid
0.0031	-	pH and temperature not specified in the publication	Homo sapiens	4-(4-fluorophenyl)-3-methyl-1H-pyrazole-5-carboxylic acid
0.0032	-	pH and temperature not specified in the publication	Homo sapiens	4-(4-carboxybenzyl)-3-methyl-1H-pyrazole-5-carboxylic acid
0.0032	-	pH and temperature not specified in the publication	Homo sapiens	4-[(4'-carboxybiphenyl-3-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid
0.0042	-	pH and temperature not specified in the publication	Homo sapiens	4-[[4-(4-fluorophenyl)pyridin-2-yl]methyl]-3-(2-phenylethyl)-1H-pyrazole-5-carboxylic acid
0.00427	-	pH and temperature not specified in the publication	Rattus norvegicus	3-methyl-4-(2-phenylethyl)-1H-pyrazole-5-carboxylic acid
0.0051	-	pH and temperature not specified in the publication	Homo sapiens	3-methyl-4-[[4'-(trifluoromethyl)biphenyl-4-yl]methyl]-1H-pyrazole-5-carboxylic acid
0.0052	-	pH and temperature not specified in the publication	Homo sapiens	4-[2-(4-fluorophenyl)ethyl]-3-methyl-1H-pyrazole-5-carboxylic acid
0.0052	-	pH and temperature not specified in the publication	Homo sapiens	4-[(2'-fluorobiphenyl-3-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid
0.00523	-	pH and temperature not specified in the publication	Homo sapiens	3-methyl-4-[3-(trifluoromethyl)benzyl]-1H-pyrazole-5-carboxylic acid
0.0054	-	pH and temperature not specified in the publication	Homo sapiens	4-[2-(4'-fluorobiphenyl-4-yl)ethyl]-3-methyl-1H-pyrazole-5-carboxylic acid
0.0054	-	pH and temperature not specified in the publication	Homo sapiens	3-ethyl-4-[[4-(4-fluorophenyl)pyridin-2-yl]methyl]-1H-pyrazole-5-carboxylic acid
0.0062	-	pH and temperature not specified in the publication	Homo sapiens	4-(3-cyanobenzyl)-3-methyl-1H-pyrazole-5-carboxylic acid
0.00634	-	pH and temperature not specified in the publication	Homo sapiens	3-methyl-4-[[4'-(trifluoromethoxy)biphenyl-3-yl]methyl]-1H-pyrazole-5-carboxylic acid
0.00714	-	pH and temperature not specified in the publication	Homo sapiens	4-(4-fluorobenzyl)-3-methyl-1H-pyrazole-5-carboxylic acid
0.0073	-	pH and temperature not specified in the publication	Homo sapiens	3-methyl-4-[4-(trifluoromethoxy)benzyl]-1H-pyrazole-5-carboxylic acid
0.0076	-	pH and temperature not specified in the publication	Rattus norvegicus	4-(3-carboxybenzyl)-3-methyl-1H-pyrazole-5-carboxylic acid
0.00812	-	pH and temperature not specified in the publication	Homo sapiens	3-methyl-4-(naphthalen-2-ylmethyl)-1H-pyrazole-5-carboxylic acid
0.0083	-	pH and temperature not specified in the publication	Homo sapiens	4-(1-benzothiophen-2-ylmethyl)-3-methyl-1H-pyrazole-5-carboxylic acid
0.0083	-	pH and temperature not specified in the publication	Homo sapiens	3-methyl-4-[[4'-(trifluoromethyl)biphenyl-3-yl]methyl]-1H-pyrazole-5-carboxylic acid
0.0088	-	pH and temperature not specified in the publication	Homo sapiens	4-(3-carbamoylbenzyl)-3-methyl-1H-pyrazole-5-carboxylic acid
0.00912	-	pH and temperature not specified in the publication	Homo sapiens	3-methyl-4-[4-(trifluoromethyl)benzyl]-1H-pyrazole-5-carboxylic acid
0.0095	-	pH and temperature not specified in the publication	Homo sapiens	4-[2-(4'-fluorobiphenyl-3-yl)ethyl]-3-methyl-1H-pyrazole-5-carboxylic acid
0.0095	-	pH and temperature not specified in the publication	Homo sapiens	3-methyl-4-(2-phenoxybenzyl)-1H-pyrazole-5-carboxylic acid
0.0104	-	pH and temperature not specified in the publication	Homo sapiens	3-methyl-4-(4-phenoxybenzyl)-1H-pyrazole-5-carboxylic acid
0.0107	-	pH and temperature not specified in the publication	Rattus norvegicus	3-methyl-4-(2-phenoxybenzyl)-1H-pyrazole-5-carboxylic acid
0.0108	-	pH and temperature not specified in the publication	Homo sapiens	3-benzyl-4-[[4-(4-fluorophenyl)pyridin-2-yl]methyl]-1H-pyrazole-5-carboxylic acid
0.01125	-	pH and temperature not specified in the publication	Homo sapiens	4-[(4'-fluorobiphenyl-4-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid
0.0113	-	pH and temperature not specified in the publication	Homo sapiens	3-methyl-4-[[4'-(trifluoromethoxy)biphenyl-4-yl]methyl]-1H-pyrazole-5-carboxylic acid
0.0116	-	pH and temperature not specified in the publication	Homo sapiens	4-[(4'-fluorobiphenyl-2-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid
0.0124	-	pH and temperature not specified in the publication	Homo sapiens	3-methyl-4-(3-phenoxybenzyl)-1H-pyrazole-5-carboxylic acid
0.0134	-	pH and temperature not specified in the publication	Homo sapiens	3-methyl-4-[2-(trifluoromethyl)benzyl]-1H-pyrazole-5-carboxylic acid
0.0135	-	pH and temperature not specified in the publication	Homo sapiens	4-[(4'-cyanobiphenyl-3-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid
0.0135	-	pH and temperature not specified in the publication	Homo sapiens	3-methyl-4-[3-(pyridin-4-yl)benzyl]-1H-pyrazole-5-carboxylic acid
0.0137	-	pH and temperature not specified in the publication	Rattus norvegicus	4-(4'-fluorobiphenyl-4-yl)-3-methyl-1H-pyrazole-5-carboxylic acid
0.0166	-	pH and temperature not specified in the publication	Homo sapiens	4-[(4'-fluorobiphenyl-3-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid
0.0186	-	pH and temperature not specified in the publication	Homo sapiens	4-[(4'-carbamoylbiphenyl-3-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid
0.0196	-	pH and temperature not specified in the publication	Homo sapiens	4-(4'-fluorobiphenyl-4-yl)-3-methyl-1H-pyrazole-5-carboxylic acid
0.0205	-	pH and temperature not specified in the publication	Homo sapiens	4-[(3'-fluorobiphenyl-3-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid
0.0217	-	pH and temperature not specified in the publication	Rattus norvegicus	4-[(4'-fluorobiphenyl-2-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid
0.0226	-	pH and temperature not specified in the publication	Homo sapiens	3-methyl-4-(naphthalen-1-ylmethyl)-1H-pyrazole-5-carboxylic acid
0.0267	-	pH and temperature not specified in the publication	Homo sapiens	4-(1-benzofuran-2-ylmethyl)-3-methyl-1H-pyrazole-5-carboxylic acid
0.0315	-	pH and temperature not specified in the publication	Homo sapiens	3-methyl-4-[3-(pyridin-3-yl)benzyl]-1H-pyrazole-5-carboxylic acid
0.0318	-	pH and temperature not specified in the publication	Rattus norvegicus	4-[2-(4-fluorophenyl)ethyl]-3-methyl-1H-pyrazole-5-carboxylic acid
0.0339	-	pH and temperature not specified in the publication	Rattus norvegicus	4-(4-cyanobenzyl)-3-methyl-1H-pyrazole-5-carboxylic acid
0.0357	-	pH and temperature not specified in the publication	Rattus norvegicus	3-methyl-4-[4-(trifluoromethyl)benzyl]-1H-pyrazole-5-carboxylic acid
0.0358	-	pH and temperature not specified in the publication	Rattus norvegicus	4-(4'-fluorobiphenyl-3-yl)-3-methyl-1H-pyrazole-5-carboxylic acid
0.0407	-	pH and temperature not specified in the publication	Rattus norvegicus	4-(4-carboxybenzyl)-3-methyl-1H-pyrazole-5-carboxylic acid
0.048	-	pH and temperature not specified in the publication	Rattus norvegicus	4-(1-benzofuran-2-ylmethyl)-3-methyl-1H-pyrazole-5-carboxylic acid
11	-	pH and temperature not specified in the publication	Rattus norvegicus	4-(4-carbamoylbenzyl)-3-methyl-1H-pyrazole-5-carboxylic acid

General Information

General Information	Comment	Organism
evolution	the enzyme is a member of the flavoenzyme family	Homo sapiens
evolution	the enzyme is a member of the flavoenzyme family	Rattus norvegicus