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Literature summary for 1.1.3.15 extracted from

  • Yorita, K.; Matsuoka, T.; Misaki, H.; Massey, V.
    Interaction of two arginine residues in lactate oxidase with the enzyme flavin: Conversion of FMN to 8-formyl-FMN (2000), Proc. Natl. Acad. Sci. USA, 97, 13039-13044.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
R181K less active than wild-type Aerococcus viridans
R181K/R268K no activity Aerococcus viridans
R181M less active than wild-type Aerococcus viridans
R268K no activity Aerococcus viridans

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.029
-
 O2 R181K mutant Aerococcus viridans
0.03
-
 O2 R181M mutant Aerococcus viridans
0.16
-
 O2 wild-type Aerococcus viridans
0.94
-
 (S)-lactate wild-type Aerococcus viridans
7.5
-
 (S)-lactate R181K mutant Aerococcus viridans
103
-
 (S)-lactate R181M mutant Aerococcus viridans

Organism

Organism UniProt Comment Textmining
Aerococcus viridans
-
-
-

Cofactor

Cofactor Comment Organism Structure
FMN
-
 Aerococcus viridans