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Literature summary for 1.1.3.15 extracted from
- Metabolic pathways in peroxisomes and glyoxysomes (1981), Annu. Rev. Biochem., 50, 133-157.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| peroxisome | - |
Mammalia | 5777 | - |
| peroxisome | - |
Rattus sp. | 5777 | - |
| peroxisome | - |
plant | 5777 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-2 -hydroxyisocaproate + O2 | Rattus sp. | liver enzyme is much less active with C4 or C5 alpha-hydroxy acids but as active as with glycolate | 2-oxoisocaproate + H2O2 | - |
? |  |
| glycolate + O2 | Mammalia | - |
glyoxylate + H2O2 | - |
? | |
| glycolate + O2 | Rattus sp. | - |
glyoxylate + H2O2 | - |
? | |
| glycolate + O2 | plant | - |
glyoxylate + H2O2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mammalia | - |
- |
- |
| plant | - |
- |
- |
| Rattus sp. | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Mammalia | - |
| kidney | - |
Rattus sp. | - |
| leaf | - |
plant | - |
| liver | - |
Mammalia | - |
| liver | - |
Rattus sp. | - |
| additional information | hepatic or leaf glycolate oxidases oxidize best glycolate and alpha-hydroxyisocaproate, that from kidney oxidizes only long-chain alpha-hydroxy acids | Mammalia | - |
| additional information | hepatic or leaf glycolate oxidases oxidize best glycolate and alpha-hydroxyisocaproate, that from kidney oxidizes only long-chain alpha-hydroxy acids | Rattus sp. | - |
| additional information | hepatic or leaf glycolate oxidases oxidize best glycolate and alpha-hydroxyisocaproate, that from kidney oxidizes only long-chain alpha-hydroxy acids | plant | - |
| additional information | Kidney enzyme oxidizes only long-chain alpha-hydroxy acids. The liver enzyme also oxidizes L-amino acids | Mammalia | - |
| pancreas | - |
Mammalia | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 2.4 | 4.8 | liver enzyme | Rattus sp. |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-2 -hydroxyisocaproate + O2 | liver enzyme is much less active with C4 or C5 alpha-hydroxy acids but as active as with glycolate | Rattus sp. | 2-oxoisocaproate + H2O2 | - |
? | |
| glycolate + O2 | - |
Mammalia | glyoxylate + H2O2 | - |
? | |
| glycolate + O2 | - |
Rattus sp. | glyoxylate + H2O2 | - |
? | |
| glycolate + O2 | - |
plant | glyoxylate + H2O2 | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FMN | - |
Mammalia | |
| FMN | - |
Rattus sp. | |
| FMN | - |
plant | |
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Release 2023.1 (January 2023)
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