Literature summary for 1.1.3.15 extracted from

Ferjancic-Biagini, A.; Dupuis, L.; De Caro, J.; Puigserver, A.
Inhibitory effects of anions and active site amino acid sequence of chicken liver L-2-hydroxyacid oxidase A, a member of the FMN-dependent alpha-hydroxy acid oxidizing enzyme family (1998), Biochimie, 80, 1047-1054.

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Inhibitors

Inhibitors	Comment	Organism	Structure
acetate	mixed-type non-competitive inhibition	Gallus gallus
caproate	mixed-type non-competitive inhibition	Gallus gallus
oxalate	mixed-type non-competitive inhibition, increasing inhibitory effects as the number of carbons in aliphatic chains decreases	Gallus gallus
oxamate	mixed-type non-competitive inhibition	Gallus gallus
propionate	mixed-type non-competitive inhibition	Gallus gallus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
1.82	-	L-2-hydroxy-4-methylthiobutanoic acid	-	Gallus gallus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
peroxisome	-	Gallus gallus	5777	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-2-hydroxy-4-methylthiobutanoic acid + O2	Gallus gallus	oxidative decarboxylation	3-(methylthio)propanoate + HCO3-	-	?

Organism

Organism	UniProt	Comment	Textmining
Gallus gallus	-	chicken	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
kidney	-	Gallus gallus	-
liver	isoenzyme L-2-hydroxyacid oxidase A	Gallus gallus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-2-hydroxy-4-methylthiobutanoic acid + O2	oxidative decarboxylation	Gallus gallus	3-(methylthio)propanoate + HCO3-	-	?

Synonyms

Synonyms	Comment	Organism
L-2-hydroxyacid oxidase A	-	Gallus gallus

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
0.74	-	L-2-hydroxy-4-methylthiobutanoic acid	-	Gallus gallus

Cofactor

Cofactor	Comment	Organism	Structure
FMN	-	Gallus gallus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
3	-	caproate	-	Gallus gallus
5	-	oxalate	-	Gallus gallus
126	-	propionate	-	Gallus gallus
171	-	oxamate	-	Gallus gallus
494	-	acetate	decreasing values as the number of carbons in the alkyl side chain increases from 1 to 2 and to 5	Gallus gallus

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Release 2023.1 (January 2023)