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Literature summary for 1.1.3.15 extracted from

  • Jones, J.M.; Morrell, J.C.; Gould, S.J.
    Identification and characterization of HAOX1, HAOX2, and HAOX3, three human peroxisomal 2-hydroxy acid oxidases (2000), J. Biol. Chem., 275, 12590-12597.
    View publication on PubMed
Search for more literature for 1.1.3.15

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli, expression in human skin fibroblasts Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.045
-
 2-Hydroxyoctanoate isoenzyme HAOX3 Homo sapiens
0.12
-
 glycolate isoenzyme HAOX1 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
peroxisome
-
 Homo sapiens 5777
-
peroxisome
-
 Rattus sp. 5777
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-hydroxyoctanoate + O2 Homo sapiens substrates for isoenzymes HAOX1, HAOX2, preferred substrate for isoenzyme HAOX3 2-oxooctanoate + H2O2
-
 ?
2-hydroxypalmitate + O2 Homo sapiens substrates for isoenzymes HAOX1, HAOX2 2-oxopalmitate + H2O2
-
 ?
glycolate + O2 Rattus sp.
-
 glyoxylate + H2O2
-
 ?
glycolate + O2 Homo sapiens highest activity for isoenzyme HAOX1, no activity for isoenzymes HAOX2, HAOX3 glyoxylate + H2O2
-
 ?
glyoxylate + O2 Rattus sp.
-
 ? + H2O2
-
 ?
glyoxylate + O2 Homo sapiens substrate for isoenzyme HAOX1 ? + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus sp.
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant isoenzymes Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Rattus sp.
-
kidney distribution of isoenzyme HAOX2 Homo sapiens
-
liver
-
 Rattus sp.
-
liver distribution of isoenzymes HAOX1, HAOX2 Homo sapiens
-
pancreas distribution of isoenzymes HAOX1, HAOX3 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-hydroxyoctanoate + O2 substrates for isoenzymes HAOX1, HAOX2, preferred substrate for isoenzyme HAOX3 Homo sapiens 2-oxooctanoate + H2O2
-
 ?
2-hydroxypalmitate + O2 substrates for isoenzymes HAOX1, HAOX2 Homo sapiens 2-oxopalmitate + H2O2
-
 ?
glycolate + O2
-
 Rattus sp. glyoxylate + H2O2
-
 ?
glycolate + O2 highest activity for isoenzyme HAOX1, no activity for isoenzymes HAOX2, HAOX3 Homo sapiens glyoxylate + H2O2
-
 ?
glyoxylate + O2
-
 Rattus sp. ? + H2O2
-
 ?
glyoxylate + O2 substrate for isoenzyme HAOX1 Homo sapiens ? + H2O2
-
 ?

Cofactor

Cofactor Comment Organism Structure
FMN
-
 Homo sapiens
FMN
-
 Rattus sp.