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Literature summary for 1.1.2.8 extracted from
- Functional role of lanthanides in enzymatic activity and transcriptional regulation of pyrroloquinoline quinone-dependent alcohol dehydrogenases in Pseudomonas putida KT2440 (2017), mBio, 8, e00570-17 .
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.085 | - |
ethanol | pH 8.0, 30°C | Pseudomonas putida |  |
| 0.115 | - |
2-phenylethanol | pH 8.0, 30°C | Pseudomonas putida | |
| 0.899 | - |
acetaldehyde | pH 8.0, 30°C | Pseudomonas putida | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | the enzyme is only active in the presence of Ca2+ | Pseudomonas putida | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pseudomonas putida | Q88JH5 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-butanol + phenazine methosulfate | - |
Pseudomonas putida | butanal + reduced phenazine methosulfate | - |
? | |
| 1-hexanol + phenazine methosulfate | - |
Pseudomonas putida | hexanal + reduced phenazine methosulfate | - |
? | |
| 1-octanol + phenazine methosulfate | - |
Pseudomonas putida | octanal + reduced phenazine methosulfate | - |
? | |
| 2,3-butanediol + phenazine methosulfate | - |
Pseudomonas putida | ? + reduced phenazine methosulfate | - |
? | |
| 2-butanol + phenazine methosulfate | - |
Pseudomonas putida | butan-2-one + reduced phenazine methosulfate | - |
? | |
| 2-phenylethanol + phenazine methosulfate | - |
Pseudomonas putida | phenylacetaldehyde + reduced phenazine methosulfate | - |
? | |
| acetaldehyde + phenazine methosulfate | - |
Pseudomonas putida | ? + reduced phenazine methosulfate | - |
? | |
| butyraldehyde + phenazine methosulfate | - |
Pseudomonas putida | ? + reduced phenazine methosulfate | - |
? | |
| cinnamyl alcohol + phenazine methosulfate | - |
Pseudomonas putida | cinnamyl aldehyde + reduced phenazine methosulfate | - |
? | |
| ethanol + phenazine methosulfate | - |
Pseudomonas putida | acetaldehyde + reduced phenazine methosulfate | - |
? | |
| ethanolamine + phenazine methosulfate | - |
Pseudomonas putida | ? + reduced phenazine methosulfate | - |
? | |
| farnesol + phenazine methosulfate | - |
Pseudomonas putida | farnesal + reduced phenazine methosulfate | - |
? | |
| hexanal + phenazine methosulfate | - |
Pseudomonas putida | ? + reduced phenazine methosulfate | - |
? | |
| methanol + phenazine methosulfate | - |
Pseudomonas putida | formaldehyde + reduced phenazine methosulfate | - |
? | |
| octanal + phenazine methosulfate | - |
Pseudomonas putida | ? + reduced phenazine methosulfate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Ca2+-dependent PQQ-ADH | - |
Pseudomonas putida |
| PedE | - |
Pseudomonas putida |
| pyrroloquinoline quinone-dependent alcohol dehydrogenases | - |
Pseudomonas putida |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | functional redundancy and inverse regulation of PedE (Ca2+-dependent PQQ-ADH) and PedH (lanthanide-dependent PQQ-ADH) represent an adaptive strategy of Pseudomonas putida KT2440 to optimize growth with volatile alcohols in response to the availability of different lanthanides | Pseudomonas putida |
kcat/KM [mM/s]
| kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.007 | - |
acetaldehyde | pH 8.0, 30°C | Pseudomonas putida | |
| 0.051 | - |
2-phenylethanol | pH 8.0, 30°C | Pseudomonas putida | |
| 0.081 | - |
ethanol | pH 8.0, 30°C | Pseudomonas putida | |
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