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Literature summary for 1.1.2.3 extracted from

  • Hatefi, Y.; Stiggall, D.L.
    Metal-containing flavoprotein dehydrogenases (1976), The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ), 13, 175-297.
No PubMed abstract available
Search for more literature for 1.1.2.3

Inhibitors

Inhibitors Comment Organism Structure
L-lactate inhibition by excess of substrate, no inhibition with Saccharomyces cerevisiae enzyme Wickerhamomyces anomalus
p-mercuribenzoate
-
 Saccharomyces cerevisiae

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ bound to enzyme Saccharomyces cerevisiae
Fe2+ bound to enzyme Wickerhamomyces anomalus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
58600
-
 4 * 58600, calculated bases on amino acid sequence and heme extinction coefficient Saccharomyces cerevisiae
61000
-
 4 * 61000 Wickerhamomyces anomalus
235000
-
 X-ray diffraction studies Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-lactate + 2 ferricytochrome c Wickerhamomyces anomalus
-
 pyruvate + 2 ferrocytochrome c + 2 H+
-
 ?
(S)-lactate + 2 ferricytochrome c Saccharomyces cerevisiae can feed electrons to respiratory chain at the level of cytochrome c pyruvate + 2 ferrocytochrome c + 2 H+
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-
Wickerhamomyces anomalus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-lactate + 2 ferricytochrome c
-
 Wickerhamomyces anomalus pyruvate + 2 ferrocytochrome c + 2 H+
-
 ?
(S)-lactate + 2 ferricytochrome c D-isomer not oxidized Saccharomyces cerevisiae pyruvate + 2 ferrocytochrome c + 2 H+
-
 ?
(S)-lactate + 2 ferricytochrome c can feed electrons to respiratory chain at the level of cytochrome c Saccharomyces cerevisiae pyruvate + 2 ferrocytochrome c + 2 H+
-
 ?
additional information 2,6-dichloroindophenol, ferricyanide, methylene blue, 1,2-naphthoquinone and cytochrome c can serve as electron acceptors Saccharomyces cerevisiae ?
-
 ?
additional information electron acceptors other than ferricytochrome c used Saccharomyces cerevisiae ?
-
 ?
additional information electron acceptors other than ferricytochrome c used Wickerhamomyces anomalus ?
-
 ?

Subunits

Subunits Comment Organism
tetramer 4 * 61000 Wickerhamomyces anomalus
tetramer 4 * 58600, calculated bases on amino acid sequence and heme extinction coefficient Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
cytochrome c
-
 Saccharomyces cerevisiae
cytochrome c
-
 Wickerhamomyces anomalus
FMN one FMN per subunit Saccharomyces cerevisiae
FMN one FMN per subunit Wickerhamomyces anomalus
heme one heme per subunit Saccharomyces cerevisiae
heme one heme per subunit Wickerhamomyces anomalus
additional information electron acceptors other than ferricytochrome c used Saccharomyces cerevisiae
additional information electron acceptors other than ferricytochrome c used Wickerhamomyces anomalus
additional information 2,6-dichloroindophenol, ferricyanide, methylene blue, 1,2-naphthoquinone and cytochrome c can serve as electron acceptors Saccharomyces cerevisiae