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Literature summary for 1.1.1.B40 extracted from

  • Heussner, K.; Ruebner, M.; Huebner, H.; Rascher, W.; Menendez-Castro, C.; Hartner, A.; Fahlbusch, F.B.; Rauh, M.
    Species differences of 11beta-hydroxysteroid dehydrogenase type 2 function in human and rat term placenta determined via LC-MS/MS (2016), Placenta, 37, 79-84 .
    View publication on PubMed
Search for more literature for 1.1.1.B40

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-
microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
corticosterone + beta-NAD+ Rattus norvegicus
-
 11-dehydrocorticosterone + beta-NADH
-
 r
corticosterone + beta-NAD+ Homo sapiens
-
 11-dehydrocorticosterone + beta-NADH
-
 r
corticosterone + beta-NAD+ Rattus norvegicus Wistar
-
 11-dehydrocorticosterone + beta-NADH
-
 r
cortisol + beta-NAD+ Rattus norvegicus
-
 cortisone + beta-NADH
-
 r
cortisol + beta-NAD+ Homo sapiens
-
 cortisone + beta-NADH
-
 r
cortisol + beta-NAD+ Rattus norvegicus Wistar
-
 cortisone + beta-NADH
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens P80365
-
-
Rattus norvegicus
-
-
-
Rattus norvegicus Wistar
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
 Rattus norvegicus
-
placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
11-dehydrocorticosterone + beta-NADPH low activity Homo sapiens corticosterone + beta-NADP+
-
 r
11-dehydrocorticosterone + beta-NADPH higher activity Rattus norvegicus corticosterone + beta-NADP+
-
 r
11-dehydrocorticosterone + beta-NADPH higher activity Rattus norvegicus Wistar corticosterone + beta-NADP+
-
 r
corticosterone + beta-NAD+
-
 Rattus norvegicus 11-dehydrocorticosterone + beta-NADH
-
 r
corticosterone + beta-NAD+
-
 Homo sapiens 11-dehydrocorticosterone + beta-NADH
-
 r
corticosterone + beta-NAD+
-
 Rattus norvegicus Wistar 11-dehydrocorticosterone + beta-NADH
-
 r
cortisol + beta-NAD+
-
 Rattus norvegicus cortisone + beta-NADH
-
 r
cortisol + beta-NAD+
-
 Homo sapiens cortisone + beta-NADH
-
 r
cortisol + beta-NAD+ low activity Rattus norvegicus cortisone + beta-NADH
-
 r
cortisol + beta-NAD+ higher activity Homo sapiens cortisone + beta-NADH
-
 r
cortisol + beta-NAD+
-
 Rattus norvegicus Wistar cortisone + beta-NADH
-
 r
cortisol + beta-NAD+ low activity Rattus norvegicus Wistar cortisone + beta-NADH
-
 r
cortisone + beta-NADPH low activity Homo sapiens cortisol + beta-NADP+
-
 r
cortisone + beta-NADPH higher activity Rattus norvegicus cortisol + beta-NADP+
-
 r
cortisone + beta-NADPH higher activity Rattus norvegicus Wistar cortisol + beta-NADP+
-
 r

Synonyms

Synonyms Comment Organism
11beta-HSD2
-
 Rattus norvegicus
11beta-HSD2
-
 Homo sapiens
11beta-hydroxysteroid dehydrogenase type 2
-
 Rattus norvegicus
11beta-hydroxysteroid dehydrogenase type 2
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
 sterid reduction assay at Homo sapiens
6.5
-
 steroid reduction assay at Rattus norvegicus
8
-
 steroid oxidation assay at Rattus norvegicus
8
-
 steroid oxidation assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Rattus norvegicus
NAD+
-
 Homo sapiens
NADH
-
 Rattus norvegicus
NADH
-
 Homo sapiens
NADP+
-
 Rattus norvegicus
NADP+
-
 Homo sapiens
NADPH
-
 Rattus norvegicus
NADPH
-
 Homo sapiens

General Information

General Information Comment Organism
additional information species-specific differences of rat and human placental 11beta-HSD2 steroid turnover, species-specific expression of corticotropin-releasing hormone and steroids in human and rat term placenta Rattus norvegicus
additional information species-specific differences of rat and human placental 11beta-HSD2 steroid turnover, species-specific expression of corticotropin-releasing hormone and steroids in human and rat term placenta Homo sapiens
physiological function the placental enzyme 11beta-hydroxysteroid dehydrogenase type 2 (11b-HSD2) shields the fetus from maternal glucocorticoid excess by catalyzing the conversion of these hormones into biologically inactive derivatives Homo sapiens
physiological function the placental enzyme 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) shields the fetus from maternal glucocorticoid excess by catalyzing the conversion of these hormones into biologically inactive derivatives Rattus norvegicus