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Literature summary for 1.1.1.B40 extracted from
- The role and regulation of 11beta-hydroxysteroid dehydrogenase type 1 in the inflammatory response (2009), Mol. Cell. Endocrinol., 301, 123-131.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | interleukin-1beta or tissue necrosis factor-alpha simultaneously increase 11beta-HSD1 expression and down-regulate 11beta-HSD2 | Homo sapiens | |
| additional information | interleukin-1beta or tissue necrosis factor-alpha simultaneously increase 11beta-HSD1 expression and down-regulate 11beta-HSD2 | Mus musculus |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | 11beta-HSD1 is a drug target for treatment of insulin resistance, diabetes and cardiovascular disease | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| interleukin-1beta or tissue necrosis factor-alpha simultaneously increase 11beta-HSD1 expression and down-regulate 11beta-HSD2 | - |
Homo sapiens | |
| interleukin-1beta or tissue necrosis factor-alpha simultaneously increase 11beta-HSD1 expression and down-regulate 11beta-HSD2 | - |
Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| corticosterone + NAD+ | Homo sapiens | - |
11-dehydrocorticosterone + NADH + H+ | - |
ir |  |
| corticosterone + NAD+ | Mus musculus | - |
11-dehydrocorticosterone + NADH + H+ | - |
ir | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adipose tissue | - |
Homo sapiens | - |
| adipose tissue | - |
Mus musculus | - |
| aortic smooth muscle cell | - |
Homo sapiens | - |
| aortic smooth muscle cell | - |
Mus musculus | - |
| colon | - |
Homo sapiens | - |
| colon | - |
Mus musculus | - |
| granulosa cell | - |
Homo sapiens | - |
| granulosa cell | - |
Mus musculus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Mus musculus | - |
| lung | - |
Homo sapiens | - |
| lung | - |
Mus musculus | - |
| lymph node | peripheral lymph nodes and mesenteric lymph nodes | Mus musculus | - |
| MG-63 cell | - |
Homo sapiens | - |
| MG-63 cell | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| corticosterone + NAD+ | - |
Homo sapiens | 11-dehydrocorticosterone + NADH + H+ | - |
ir | |
| corticosterone + NAD+ | - |
Mus musculus | 11-dehydrocorticosterone + NADH + H+ | - |
ir | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 11beta-HSD2 | - |
Homo sapiens |
| 11beta-HSD2 | - |
Mus musculus |
| 11beta-hydroxysteroid dehydrogenase type 2 | - |
Homo sapiens |
| 11beta-hydroxysteroid dehydrogenase type 2 | - |
Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Homo sapiens | |
| NAD+ | - |
Mus musculus | |
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