Application | Comment | Organism |
---|---|---|
medicine | squirrel monkeys protect the mineralocorticoid receptor from activation by high cortisol levels in the kidney via upregulation of 11beta-HSD2 activity through increased production of the enzyme | Saimiri |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | 1beta-hydroxysteroid dehydrogenase 2 activity in suirrel monkey kidney microsomes is 3- to 7-times higher than that seen in microsomes from pig or rabbit. Enzyme protein is 4- to 9-times greater in suirrel monkey kidney microsomes than in microsomes from pig or rabbit | Sus scrofa | - |
- |
microsome | 1beta-hydroxysteroid dehydrogenase 2 activity in suirrel monkey kidney microsomes is 3- to 7-times higher than that seen in microsomes from pig or rabbit. Enzyme protein is 4- to 9-times greater in suirrel monkey kidney microsomes than in microsomes from pig or rabbit | Saimiri | - |
- |
microsome | 1beta-hydroxysteroid dehydrogenase 2 activity in suirrel monkey kidney microsomes is 3- to 7-times higher than that seen in microsomes from pig or rabbit. Enzyme protein is 4- to 9-times greater in suirrel monkey kidney microsomes than in microsomes from pig or rabbit | Oryctolagus cuniculus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | P51976 | isoform 11beta-HSD2 | - |
Saimiri | - |
isoform 11beta-HSD2 | - |
Sus scrofa | - |
isoform 11beta-HSD2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Sus scrofa | - |
kidney | - |
Saimiri | - |
kidney | - |
Oryctolagus cuniculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
the intrinsic activities of squirrel monkey and human enzyme are similar | Saimiri |