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Literature summary for 1.1.1.B40 extracted from
- The forms and functions of 11beta-hydroxysteroid dehydrogenase (1993), J. Steroid Biochem. Mol. Biol., 45, 161-165.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in CHO cells | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3beta-hydroxy-11-oxo-18beta-olean-12-en-30-oic-acid | i.e. glycyrrhetinic acid; more effective for 11-dehydrogenase than for 11-oxoreductase activity | Rattus norvegicus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+ | Rattus norvegicus | i.e. corticosterone | 21-hydroxy-pregn-4-en-3,11,20-trione + NADH | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+ | i.e. corticosterone | Rattus norvegicus | 21-hydroxy-pregn-4-en-3,11,20-trione + NADH | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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