Literature summary for 1.1.1.95 extracted from

Zhang, W.; Zhang, M.; Gao, C.; Zhang, Y.; Ge, Y.; Guo, S.; Guo, X.; Zhou, Z.; Liu, Q.; Zhang, Y.; Ma, C.; Tao, F.; Xu, P.
Coupling between D-3-phosphoglycerate dehydrogenase and D-2-hydroxyglutarate dehydrogenase drives bacterial L-serine synthesis (2017), Proc. Natl. Acad. Sci. USA, 114, E7574-E7582 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Pseudomonas stutzeri	5737	-
cytoplasm	-	Pseudomonas aeruginosa	5737	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3-phospho-D-glycerate + NAD+	Pseudomonas stutzeri	-	3-phosphooxypyruvate + NADH + H+	-	r
3-phospho-D-glycerate + NAD+	Pseudomonas aeruginosa	-	3-phosphooxypyruvate + NADH + H+	-	r
3-phospho-D-glycerate + NAD+	Pseudomonas stutzeri A1501	-	3-phosphooxypyruvate + NADH + H+	-	r

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas aeruginosa	Q9I6H5	-	-
Pseudomonas stutzeri	A4VGK3	-	-
Pseudomonas stutzeri A1501	A4VGK3	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3-phospho-D-glycerate + NAD+	-	Pseudomonas stutzeri	3-phosphooxypyruvate + NADH + H+	-	r
3-phospho-D-glycerate + NAD+	-	Pseudomonas aeruginosa	3-phosphooxypyruvate + NADH + H+	-	r
3-phospho-D-glycerate + NAD+	-	Pseudomonas stutzeri A1501	3-phosphooxypyruvate + NADH + H+	-	r

Synonyms

Synonyms	Comment	Organism
D-3-PG dehydrogenase	-	Pseudomonas stutzeri
D-3-PG dehydrogenase	-	Pseudomonas aeruginosa
D-3-phosphoglycerate dehydrogenase	-	Pseudomonas stutzeri
D-3-phosphoglycerate dehydrogenase	-	Pseudomonas aeruginosa
Phgdh	-	Pseudomonas stutzeri
Phgdh	-	Pseudomonas aeruginosa
serA	-	Pseudomonas stutzeri
serA	-	Pseudomonas aeruginosa

General Information

General Information	Comment	Organism
metabolism	key enzyme in L-serine biosynthesis. The coupling between D-3-phosphoglycerate dehydrogenase (SerA) and D-2-hydroxyglutarate dehydrogenase (D2HGDH) sits in the hub of L-serine biosynthesis and establishes a linkage among intermediates in glycolysis, TCA cycle, and amino acid biosynthesis. The reactions catalyzed by cytoplasmic SerA and mitochondrial D2HGDH may be coupled through the shuttle of 2-ketoglutarate and D-2-hydroxyglutarate between the cytosol and mitochondrial matrix	Pseudomonas stutzeri
metabolism	key enzyme in L-serine biosynthesis. The coupling between D-3-phosphoglycerate dehydrogenase (SerA) and D-2-hydroxyglutarate dehydrogenase (D2HGDH) sits in the hub of L-serine biosynthesis and establishes a linkage among intermediates in glycolysis, TCA cycle, and amino acid biosynthesis. The reactions catalyzed by cytoplasmic SerA and mitochondrial D2HGDH may be coupled through the shuttle of 2-ketoglutarate and D-2-hydroxyglutarate between the cytosol and mitochondrial matrix	Pseudomonas aeruginosa

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Release 2023.1 (January 2023)