Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.95 extracted from

  • Spillier, Q.; Ravez, S.; Unterlass, J.; Corbet, C.; Degavre, C.; Feron, O.; Frederick, R.
    Structure-activity relationships (SARs) of alpha-ketothioamides as inhibitors of phosphoglycerate dehydrogenase (PHGDH) (2020), Pharmaceuticals, 13, 20 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-(2,4-dichlorophenyl)-2-morpholino-2-thioxoethan-1-one
-
Homo sapiens
1-(4-chlorophenyl)-2-morpholino-2-thioxoethan-1-one
-
Homo sapiens
2-(4-methylpiperidin-1-yl)-1-phenyl-2-thioxoethan-1-one
-
Homo sapiens
2-morpholino-1-phenyl-2-thioxoethan-1-one
-
Homo sapiens
morpholino(phenyl)methanethione
-
Homo sapiens
N-morpholinobenzenesulfonamide
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0304
-
NAD+ pH 8.5, temperature not specified in the publication Homo sapiens
0.294
-
3-phospho-D-glycerate pH 8.5, temperature not specified in the publication Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O43175
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-phospho-D-glycerate + NAD+
-
Homo sapiens 3-phosphooxypyruvate + NADH + H+
-
r
3-phosphooxypyruvate + NADH + H+
-
Homo sapiens 3-phospho-D-glycerate + NAD+
-
r

Synonyms

Synonyms Comment Organism
Phgdh
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens
NADH
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0203
-
pH 8.5, temperature not specified in the publication Homo sapiens 1-(4-chlorophenyl)-2-morpholino-2-thioxoethan-1-one
0.077
-
pH 8.5, temperature not specified in the publication Homo sapiens 1-(2,4-dichlorophenyl)-2-morpholino-2-thioxoethan-1-one
0.0851
-
pH 8.5, temperature not specified in the publication Homo sapiens 2-(4-methylpiperidin-1-yl)-1-phenyl-2-thioxoethan-1-one
0.0921
-
pH 8.5, temperature not specified in the publication Homo sapiens N-morpholinobenzenesulfonamide
0.106
-
pH 8.5, temperature not specified in the publication Homo sapiens morpholino(phenyl)methanethione
0.111
-
pH 8.5, temperature not specified in the publication Homo sapiens 2-morpholino-1-phenyl-2-thioxoethan-1-one

General Information

General Information Comment Organism
metabolism the enzyme catalyzes the rate limiting step in serine biosynthesis pathway Homo sapiens