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Literature summary for 1.1.1.95 extracted from
- Biochemical insight into redox regulation of plastidial 3-phosphoglycerate dehydrogenase from Arabidopsis thaliana (2020), J. Biol. Chem., 295, 14906-14915 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli Rosetta (DE3) pLysS competent cells | Arabidopsis thaliana |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| chloroplast | - |
Arabidopsis thaliana | 9507 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-phospho-D-glycerate + NAD+ | Arabidopsis thaliana | - |
3-phosphooxypyruvate + NADH + H+ | - |
r |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arabidopsis thaliana | O04130 | - |
- |
| Arabidopsis thaliana | O49485 | - |
- |
| Arabidopsis thaliana | Q9LT69 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Arabidopsis thaliana |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-phospho-D-glycerate + NAD+ | - |
Arabidopsis thaliana | 3-phosphooxypyruvate + NADH + H+ | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 3-phosphoglycerate dehydrogenase | - |
Arabidopsis thaliana |
| At1g17745 | - |
Arabidopsis thaliana |
| At3g19480 | - |
Arabidopsis thaliana |
| At4g34200 | - |
Arabidopsis thaliana |
| PGDH1 | - |
Arabidopsis thaliana |
| PGDH2 | - |
Arabidopsis thaliana |
| PGDH3 | - |
Arabidopsis thaliana |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | the enzyme catalyzes the first committed step of Ser biosynthetic pathway in plastids. Activity of PGDH2 is not enhanced upon reduction by thioredoxin | Arabidopsis thaliana |
| metabolism | the enzyme catalyzes the first committed step of Ser biosynthetic pathway in plastids. Activity of PGDH3 is not enhanced upon reduction by thioredoxin | Arabidopsis thaliana |
| metabolism | the enzyme catalyzes the first committed step of Ser biosynthetic pathway in plastids. Isoform PGDH1 forms the intramolecular disulfide bond between Cys86 and Cys102, lowering PGDH enzyme activity. It is activated by cleavage of intramolecular disulfide bond. Some thioredoxin subtypes in plastids support PGDH1 reductive activation. PGDH1 is a redox-sensitive protein whose activity is enhanced upon reduction | Arabidopsis thaliana |
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Release 2023.1 (January 2023)
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