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Literature summary for 1.1.1.95 extracted from
- D-3-phosphoglycerate dehydrogenase from the silkworm Bombyx mori Identification, functional characterization, and expression (2021), Arch. Insect Biochem. Physiol., 106, e21751 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Bombyx mori |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.027 | - |
3-phosphooxypyruvate | pH and temperature not specified in the publication | Bombyx mori |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bombyx mori | H9JRZ9 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Bombyx mori |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| midgut | high expression levels of bmphgdh messenger RNA (mRNA) | Bombyx mori | - |
| silk gland | high expression levels of bmphgdh messenger RNA (mRNA) | Bombyx mori | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-phosphooxypyruvate + NADH + H+ | - |
Bombyx mori | 3-phospho-D-glycerate + NAD+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| D-3-phosphoglycerate dehydrogenase | - |
Bombyx mori |
| Phgdh | - |
Bombyx mori |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
- |
Bombyx mori |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 20 | 50 | at temperatures of 20-50°C, the activity of the enzyme is greater than 80% of maximal activity | Bombyx mori |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
- |
Bombyx mori |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 4 | 9 | pH 4.0: about 82% of maximal activity, pH 9.0: about 80% of maximal activity | Bombyx mori |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADH | no activity in presence of NADPH | Bombyx mori | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Bombyx mori | a sericin-deficient silkworm strain displays reduced expression of bmphgdh mRNA | down |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | key enzyme involved in the synthesis of L-serine. Might play a crucial role in the provision of L-serine in the larva of Bombyx mori | Bombyx mori |
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Release 2023.1 (January 2023)
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