Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | HOAX expression downregulates the enzyme by 40% | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | HOXA10 is required for enzyme regulation in the endometrium | ? | - |
? | |
additional information | Homo sapiens | HOXA10 is required for enzyme regulation in the endometrium | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O43175 | - |
- |
Mus musculus | Q61753 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endometrium | high expression levels in the proliferative phase | Homo sapiens | - |
uterine endometrium | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | HOXA10 is required for enzyme regulation in the endometrium | Mus musculus | ? | - |
? | |
additional information | HOXA10 is required for enzyme regulation in the endometrium | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3-PGDH | - |
Mus musculus |
3-PGDH | - |
Homo sapiens |
3-phosphoglycerate dehydrogenase | - |
Mus musculus |
3-phosphoglycerate dehydrogenase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | HOXA10 is required for enzyme regulation in the endometrium, HOAX sense expression causes a 2.0fold downregulation of 3-PGDH in endometrial cells | down |
Homo sapiens | HOXA10 is required for enzyme regulation in the endometrium, HOAX antisense expression, siRNA, causes a 4.4fold upregulation of 3-PGDH in endometrial cells | up |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme is required for the de novo biosynthesis of L-serine | Mus musculus |
metabolism | the enzyme is required for the de novo biosynthesis of L-serine | Homo sapiens |