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Literature summary for 1.1.1.95 extracted from
- Amino acid residue mutations uncouple cooperative effects in Escherichia coli D-3-phosphoglycerate dehydrogenase (2001), J. Biol. Chem., 276, 17844-17850.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| diverse mutants expressed in Escherichia coli | Escherichia coli |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | diverse mutants with different interaction between the 3 binding domains of each of 4 subunits and modified kinetics | Escherichia coli |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| L-serine | sigmoidal binding curve with mutant G294V/G336V, mutants with decreased sensitivity to serine | Escherichia coli |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| diverse mutants expressed in Escherichia coli | Escherichia coli |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| 3-phospho-D-glycerate + NAD+ = 3-phosphooxypyruvate + NADH + H+ | model for catalytic mechanism | Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-phosphoglycerate + NAD+ | - |
Escherichia coli | 3-phosphohydroxypyruvate + NADH | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | subunit structure with substrate binding domain, coenzyme binding domain and regulatory domain, active sites | Escherichia coli |
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Release 2023.1 (January 2023)
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