Any feedback?
Literature summary for 1.1.1.87 extracted from
- Thiahomoisocitrate: a highly potent inhibitor of homoisocitrate dehydrogenase involved in the alpha-aminoadipate pathway (2008), Bioorg. Med. Chem., 16, 3372-3376.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3-[(carboxymethyl)sulfanyl]-2-oxopropanoic acid | - |
Saccharomyces cerevisiae |  |
| trisodium (2S,3R)-2-(carboxylatomethoxy)-3-hydroxybutanedioate | - |
Saccharomyces cerevisiae | |
| trisodium (2S,3R)-2-[(carboxylatomethyl)amino]-3-hydroxybutanedioate | - |
Saccharomyces cerevisiae | |
| trisodium (2S,3S)-2-[(carboxylatomethyl)sulfanyl]-3-hydroxybutanedioate | - |
Saccharomyces cerevisiae | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.018 | - |
homoisocitrate | - |
Saccharomyces cerevisiae | |
| 0.02 | - |
trisodium (2S,3R)-2-(carboxylatomethoxy)-3-hydroxybutanedioate | - |
Saccharomyces cerevisiae | |
| 0.15 | - |
trisodium (2S,3R)-2-[(carboxylatomethyl)amino]-3-hydroxybutanedioate | - |
Saccharomyces cerevisiae | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Saccharomyces cerevisiae | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| homoisocitrate + NAD+ | - |
Saccharomyces cerevisiae | alpha-ketoadipate + NADH + CO2 | - |
r | |
| trisodium (2S,3R)-2-(carboxylatomethoxy)-3-hydroxybutanedioate + NAD+ | - |
Saccharomyces cerevisiae | ? + NADH + CO2 | - |
? | |
| trisodium (2S,3R)-2-[(carboxylatomethyl)amino]-3-hydroxybutanedioate + NAD+ | - |
Saccharomyces cerevisiae | ? + NADH + CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| homoisocitrate dehydrogenase | - |
Saccharomyces cerevisiae |
| ScHICDH | - |
Saccharomyces cerevisiae |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.59 | - |
trisodium (2S,3R)-2-(carboxylatomethoxy)-3-hydroxybutanedioate | - |
Saccharomyces cerevisiae | |
| 2 | - |
trisodium (2S,3R)-2-[(carboxylatomethyl)amino]-3-hydroxybutanedioate | - |
Saccharomyces cerevisiae | |
| 17 | - |
homoisocitrate | - |
Saccharomyces cerevisiae | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.8 | - |
assay at | Saccharomyces cerevisiae |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.000097 | - |
trisodium (2S,3S)-2-[(carboxylatomethyl)sulfanyl]-3-hydroxybutanedioate | - |
Saccharomyces cerevisiae | |
| 0.01 | - |
trisodium (2S,3R)-2-(carboxylatomethoxy)-3-hydroxybutanedioate | - |
Saccharomyces cerevisiae | |
| 12 | - |
3-[(carboxymethyl)sulfanyl]-2-oxopropanoic acid | - |
Saccharomyces cerevisiae | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
