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Literature summary for 1.1.1.87 extracted from
- Homoisocitric Dehydrogenase (1971), Methods Enzymol., 17B, 118-119.
No PubMed abstract available
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.4 | - |
homoisocitric acid | - |
Saccharomyces cerevisiae |  |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Saccharomyces cerevisiae | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-hydroxy-1,2,4-butanetricarboxylate + NAD+ | Saccharomyces cerevisiae | - |
2-oxoadipate + CO2 + NADH | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-hydroxy-1,2,4-butanetricarboxylate + NAD+ | - |
Saccharomyces cerevisiae | 2-oxoadipate + CO2 + NADH | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.8 | - |
homocitrate + NAD+ | Saccharomyces cerevisiae |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | NADP+ can replace NAD+ | Saccharomyces cerevisiae | |
| NADP+ | NADP+ can replace NAD+ | Saccharomyces cerevisiae | |
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Release 2023.1 (January 2023)
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