Literature summary for 1.1.1.8 extracted from

Gao, Y.Z.; Jiang, Y.; Wu, X.; Bai, C.Y.; Pan, Y.C.; Sun, Y.Z.
Molecular characteristics and expression profiles of glycerol-3-phosphate dehydrogenase 1 (GPD1) gene in pig (2011), Mol. Biol. Rep., 38, 1875-1881.

Search for more literature for 1.1.1.8

Cloned(Commentary)

Cloned (Comment)	Organism
GPD1, phylogenetic analysis, relative quantitative real-time PCR, expression of GFP-tagged GPD1 in PK-15 cells	Sus scrofa

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Sus scrofa	5829	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
37742	-	x * 37742, calculated	Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
sn-glycerol 3-phosphate + NAD+	Sus scrofa	-	glycerone phosphate + NADH + H+	-	r
sn-glycerol 3-phosphate + NAD+	Sus scrofa Duroc x Yorkshire x Landrace	-	glycerone phosphate + NADH + H+	-	r

Organism

Organism	UniProt	Comment	Textmining
Sus scrofa	-	-	-
Sus scrofa	D2XN65	-	-
Sus scrofa Duroc x Yorkshire x Landrace	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
adipose tissue	higher expression level	Sus scrofa	-
cerebellum	-	Sus scrofa	-
cerebellum	and longissimus dorsi muscle, similar expression pattern that is at a low level at birth and increasing with aging to the highest level at postnatal day 8 in longissinus doris muscle and postnatal day 14 in cerebrum. Weaning decreases the expression level of the GPD1 gene	Sus scrofa	-
cerebrum	very low expression level	Sus scrofa	-
duodenum	high expression level	Sus scrofa	-
heart	very low expression level	Sus scrofa	-
ileum	-	Sus scrofa	-
jejunum	very low expression level	Sus scrofa	-
kidney	-	Sus scrofa	-
liver	-	Sus scrofa	-
longissimus dorsi	and cerebellum, similar expression pattern that is at a low level at birth and increasing with aging to the highest level at postnatal day 8 in longissinus dorsi muscle and postnatal day 14 in cerebrum. Weaning decreases the expression level of the GPD1 gene	Sus scrofa	-
additional information	porcine GPD1 gene is expressed in almost all tissues but its levels of expression vary widely over 2 orders of magnitude	Sus scrofa	-
muscle	-	Sus scrofa	-
pancreas	very low expression level	Sus scrofa	-
spleen	very low expression level	Sus scrofa	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
sn-glycerol 3-phosphate + NAD+	-	Sus scrofa	glycerone phosphate + NADH + H+	-	r
sn-glycerol 3-phosphate + NAD+	-	Sus scrofa Duroc x Yorkshire x Landrace	glycerone phosphate + NADH + H+	-	r

Subunits

Subunits	Comment	Organism
?	x * 37742, calculated	Sus scrofa

Synonyms

Synonyms	Comment	Organism
glycerol-3-phosphate dehydrogenase 1	-	Sus scrofa
GPD1	-	Sus scrofa

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Sus scrofa
NADH	-	Sus scrofa

Expression

Organism	Comment	Expression
Sus scrofa	porcine GPD1 gene is expressed in almost all tissues but its levels of expression vary widely over 2 orders of magnitude. Longissinus doris muscle and cerebrum have a similar expression pattern that is at a low level at birth and increasing with aging to the highest level at postnatal day 8 in longissinus doris muscle and postnatal day 14 in cerebrum. Weaning decreases the expression level of the GPD1 gene	additional information

General Information

General Information	Comment	Organism
physiological function	the cytosolic activity of glycerol-3-phosphate dehydrogenase 1 plays an important role in the synthesis of triacylglycerol and in the transport of reducing equivalents from the cytosol to mitochondria	Sus scrofa

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Release 2023.1 (January 2023)