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Literature summary for 1.1.1.79 extracted from
- The ORF YNL274c (GOR1) codes for glyoxylate reductase in Saccharomyces cerevisiae (2007), Yeast, 24, 129-136.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| ORF YNL274c, DNA and amino acid sequence determination and analysis, expression in yeast strains, overview | Saccharomyces cerevisiae |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | deletion of the glyoxylate reductase-encoding gene leads to higher biomass concentration after diauxic shift, overview | Saccharomyces cerevisiae |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glyoxylate + NADPH + H+ | Saccharomyces cerevisiae | - |
glycolate + NADP+ | - |
r |  |
| glyoxylate + NADPH + H+ | Saccharomyces cerevisiae BY4742 | - |
glycolate + NADP+ | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
ORF YNL274c | - |
| Saccharomyces cerevisiae BY4742 | - |
ORF YNL274c | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
activities of wild-type and mutant strains, overview | Saccharomyces cerevisiae |
| 0.04 | - |
strain BY4742, substrate glyoxylate | Saccharomyces cerevisiae |
| 13.8 | - |
purified recombinant enzyme, substrate glyoxylate | Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-oxoisocaproate + NADPH + H+ | low activity | Saccharomyces cerevisiae | 2-hydroxy-4-methylpentanoate + NADP+ | - |
? | |
| 2-oxoisocaproate + NADPH + H+ | low activity | Saccharomyces cerevisiae BY4742 | 2-hydroxy-4-methylpentanoate + NADP+ | - |
? | |
| glyoxylate + NADPH + H+ | - |
Saccharomyces cerevisiae | glycolate + NADP+ | - |
r | |
| glyoxylate + NADPH + H+ | - |
Saccharomyces cerevisiae BY4742 | glycolate + NADP+ | - |
r | |
| hydroxypyruvate + NADPH + H+ | 15% activity compared to glyoxylate | Saccharomyces cerevisiae | D-glycerate + NADP+ | - |
? | |
| hydroxypyruvate + NADPH + H+ | 15% activity compared to glyoxylate | Saccharomyces cerevisiae BY4742 | D-glycerate + NADP+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GOR1 | - |
Saccharomyces cerevisiae |
| More | cf. EC 1.1.1.26 | Saccharomyces cerevisiae |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Saccharomyces cerevisiae |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
assay at | Saccharomyces cerevisiae |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADP+ | - |
Saccharomyces cerevisiae | |
| NADPH | preferred cofactor, NADH gives only 4% of the activity with NADPH | Saccharomyces cerevisiae | |
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Release 2023.1 (January 2023)
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