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Literature summary for 1.1.1.77 extracted from

  • Ting, S.M.; Sellinger, O.Z.; Miller, O.N.
    The metabolism of lactaldehyde VI. The reduction of D- and L-lactaldehyde in rat liver (1965), Biochim. Biophys. Acta, 89, 217-225.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
iodoacetate
-
Rattus norvegicus
N-ethylmaleimide
-
Rattus norvegicus
p-chloromercuribenzoate
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.065
-
acetaldehyde
-
Rattus norvegicus
0.26
-
ethanol
-
Rattus norvegicus
0.56
-
DL-lactaldehyde
-
Rattus norvegicus
11
-
DL-1,2-Propanediol
-
Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
extraction, heat treatment, ammonium sulfate-fractionation, DEAE-cellulose and Alumina C Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
heart
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-
lung
-
Rattus norvegicus
-
skeletal muscle
-
Rattus norvegicus
-
spleen
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-propane-1,2-diol + NAD+ utilizes D- and L-lactaldehyde in the reverse direction equally well Rattus norvegicus (R)-lactaldehyde + NADH
-
r
(S)-propane-1,2-diol + NAD+
-
Rattus norvegicus (S)-lactaldehyde + NADH
-
r
DL-1,2-propanediol + NAD+
-
Rattus norvegicus DL-lactaldehyde + NADH + H+
-
r
DL-lactaldehyde + NADH + H+
-
Rattus norvegicus DL-1,2-propanediol + NAD+
-
r
ethanol + NAD+
-
Rattus norvegicus acetaldehyde + NADH
-
r

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
-
Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
6 7.8 reduction of DL-lactaldehyde, pH 6: 50% of reductase activity maximum, pH 7.8: 45% of reductase activity maximum Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Rattus norvegicus
NADH
-
Rattus norvegicus
NADP+ one tenth of the activity as with NAD+ Rattus norvegicus