Cloned (Comment) | Organism |
---|---|
LC540 cells stably overexpress the enzyme (17beta-HSD3) | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
androstenedione + NADPH + H+ | Homo sapiens | - |
testosterone + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P37058 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
LC-540 cell | stably overexpress 17beta-HSD3 | Homo sapiens | - |
testis | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
androstenedione + NADPH + H+ | - |
Homo sapiens | testosterone + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
17beta-HSD3 | - |
Homo sapiens |
17beta-hydroxysteroid dehydrogenase type 3 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | curcumin analog H10 inhibits the production of 17beta-HSD3 in vitro. It has no effect on the expression levels of 17beta-HSD3, 3betaHSD1, CYP17alpha1, CYP11alpha1, and STAR. H10 could serve as an effective inhibitor of 17beta-HSD3, which in turn would inhibit the biosynthesis of androgens and progression of prostate cancer | down |
General Information | Comment | Organism |
---|---|---|
drug target | the enzyme is a potential therapeutic target for hormone-dependent prostate cancer | Homo sapiens |
metabolism | last step of testosterone biosynthesis | Homo sapiens |