Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.64 extracted from

  • Hu, G.X.; Zhou, H.Y.; Li, X.W.; Chen, B.B.; Xiao, Y.C.; Lian, Q.Q.; Liang, G.; Kim, H.H.; Zheng, Z.Q.; Hardy, D.O.; Ge, R.S.
    The (+)- and (-)-gossypols potently inhibit both 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase 3 in human and rat testes (2009), J. Steroid Biochem. Mol. Biol., 115, 14-19.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(+)-gossypol
-
Homo sapiens
(+)-gossypol
-
Rattus norvegicus
(-)-gossypol
-
Homo sapiens
(-)-gossypol
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-
microsome
-
Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
testis
-
Homo sapiens
-
testis
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
androstenedione + NADPH + H+ 17beta-HSD3 Homo sapiens testosterone + NADP+
-
?
androstenedione + NADPH + H+ 17beta-HSD3 Rattus norvegicus testosterone + NADP+
-
?

Synonyms

Synonyms Comment Organism
17beta-HSD3
-
Homo sapiens
17beta-HSD3
-
Rattus norvegicus
17beta-hydroxysteroid dehydrogenase 3
-
Homo sapiens
17beta-hydroxysteroid dehydrogenase 3
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens
NADPH
-
Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00036
-
in PBS buffer, pH 7.2 Homo sapiens (-)-gossypol
0.00113
-
in PBS buffer, pH 7.2 Homo sapiens (+)-gossypol
0.00343
-
in PBS buffer, pH 7.2 Rattus norvegicus (-)-gossypol
0.01093
-
in PBS buffer, pH 7.2 Rattus norvegicus (+)-gossypol